## Constraints, algebra, jommetry and such [RSABE / ABEL]

Hi ElMaestro,

» I think you don't have to worry about this. When I say it like I mean the statistics function like R's lm will take care of it.

I can see your points. Sounds great if it is correct. Never try this before since all periods of all subjects must be evaluable with bear of the current version.

» To satisfy these constraints you cannot include subjects from a 222BE study where one period is missing. I believe another way of saying this is that the model matrix cannot be inverted if we try to include such a subject.

Got it.

» This is why the lm, PROC GLM, lmer etc take the appropriate decision for you. These functions or procedures will exclude the subjects that need to be excluded...

Ok and thanks again.

All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear