Bioequivalence and Bioavailability Forum

to exclude or not to ex­clude - let the user decide [RSABE / ABEL]

posted by yjlee168  – Kaohsiung, Taiwan, 2015-03-30 13:28 (3308 d 08:11 ago) – Posting: # 14633
Views: 25,162

Dear Mittyri,

So the issue is to exclude the subject who do not have enough evaluable or all-zero data point manually or automatically. You suggest that the exclusion better be done automatically by specified the least data points by users (good idea!) as the the exclusion criteria. It should be do-able. The only question for me is how to add this option without significantly slowing down the current performance of NCA. The best way is to screen out all subjects after loading analyzed data and then execute exclusion if there is any. Assign 'NA' to all PK parameters for excluded subjects first. Then do NCA without excluded subjects. Meanwhile, I have to remember to adjust the final sample size when doing 90% CI and other stats. Ok and thanks for your suggestions.

❝ [...] In the meantime I think Bear can report to the user some helpful comments (e.g. "please be informed that only 3 evaluable points are provided for subject# in period#"). So user can make a decision: to exclude this data or not.

How a nice idea.

Complete thread:

• Statistical Analysis section of partial replicate BE study cher0424 2015-01-07 06:39 [RSABE / ABEL] 
  • Subjects to be considered in partial replicate BE study d_labes 2015-01-07 14:45
    • Subjects to be considered in partial replicate BE study cher0424 2015-01-07 15:35
    • Subjects to be considered in partial replicate BE study cher0424 2015-01-08 06:28
      • Subjects to be considered in partial replicate BE study d_labes 2015-01-08 09:03
        • Subjects to be considered in partial replicate BE study cher0424 2015-01-08 09:51
          • Subjects to be considered in partial replicate BE study d_labes 2015-01-08 10:27
            • Subjects in replicate BE study EU/FDA Shuanghe 2015-01-08 11:08
              • Subjects in replicate BE study EU/FDA cher0424 2015-01-08 13:56
              • Subjects in replicate BE study EU/FDA Relaxation 2015-03-02 09:46
                • Subjects in replicate BE study EU/FDA d_labes 2015-03-02 11:38
                • Subjects in replicate BE study EU mittyri 2015-03-19 20:12
    • Subjects to be considered in partial replicate BE study Dr_Dan 2015-01-08 08:59
      • Subjects to be considered in partial replicate BE study d_labes 2015-01-08 09:04
        • Subjects to be considered in partial replicate BE study Astea 2015-03-01 18:12
          • Subjects to be considered in partial replicate BE study yjlee168 2015-03-01 19:01
            • Subjects to be considered in partial replicate BE study Astea 2015-03-09 14:43
              • NCA with bear? yjlee168 2015-03-09 15:24
                • Bear and null PK para­meters mittyri 2015-03-25 09:50
                  • to exclude or not to ex­clude the subjects with bear? yjlee168 2015-03-28 21:03
                    • to exclude or not to ex­clude - let the user decide mittyri 2015-03-29 19:04
                      • to exclude or not to ex­clude - let the user decideyjlee168 2015-03-30 11:28
                        • to exclude or not to ex­clude - let the user decide ElMaestro 2015-03-30 15:44
                          • to exclude or not to ex­clude - let the user decide yjlee168 2015-03-31 11:15
                            • Constraints, algebra, jommetry and such ElMaestro 2015-03-31 12:16
                              • Constraints, algebra, jommetry and such yjlee168 2015-03-31 13:13
                                • Constraints, algebra, jommetry and such ElMaestro 2015-03-31 14:26
                                  • Constraints, algebra, jommetry and such mittyri 2015-04-01 08:25
                              • Proc GLM, lm() do not auto-exclude subjects d_labes 2015-04-01 09:15
                                • Proc GLM, lm() do not auto-exclude subjects ElMaestro 2015-04-01 16:29