Subjects to be considered in partial replicate BE study [RSABE / ABEL]
Dear yjlee168!
Thank you a lot for your answer! BEAR helps me greatly... Would you be so kind to answer my other silly questions?
It's a very pity...
But if it is so, why can't we use NCA data received manually for the latest statistical analyses in BEAR?
I tried to use NCA data contained unequal numbers of subjects in different periods and BEAR didn't show errors while doing statistics.
For example, we omit one of the period from the study for the N'th subject. Will the statistics compilated by BEAR be correct in such a case?
By the way, what is the reason for which BEAR couldn't calculate NCA for subjects with all zero concentrations in one of the period? In my mind, all individual pharmacokinetic parameters should be calculated independently for each period?
And the last question: am I right when thinking that for calculation CI of Cmax/AUC0t I can simply change the columns AUC0INF and lnAUCOINF for Cmax/AUC0t and ln Cmax/AUC0t respectively?
Looking forward for your answers...
Thank you a lot for your answer! BEAR helps me greatly... Would you be so kind to answer my other silly questions?
❝ It is not possible to analyze your data using bear when there is a subject with all zero concentration in one of period.
It's a very pity...
❝ It will fail when doing NCA.
But if it is so, why can't we use NCA data received manually for the latest statistical analyses in BEAR?
I tried to use NCA data contained unequal numbers of subjects in different periods and BEAR didn't show errors while doing statistics.
For example, we omit one of the period from the study for the N'th subject. Will the statistics compilated by BEAR be correct in such a case?
By the way, what is the reason for which BEAR couldn't calculate NCA for subjects with all zero concentrations in one of the period? In my mind, all individual pharmacokinetic parameters should be calculated independently for each period?

And the last question: am I right when thinking that for calculation CI of Cmax/AUC0t I can simply change the columns AUC0INF and lnAUCOINF for Cmax/AUC0t and ln Cmax/AUC0t respectively?
Looking forward for your answers...
—
"Being in minority, even a minority of one, did not make you mad"
"Being in minority, even a minority of one, did not make you mad"
Complete thread:
- Statistical Analysis section of partial replicate BE study cher0424 2015-01-07 06:39 [RSABE / ABEL]
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- to exclude or not to exclude the subjects with bear? yjlee168 2015-03-28 21:03
- to exclude or not to exclude - let the user decide mittyri 2015-03-29 19:04
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- to exclude or not to exclude - let the user decide ElMaestro 2015-03-30 15:44
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- Constraints, algebra, jommetry and such ElMaestro 2015-03-31 12:16
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- to exclude or not to exclude - let the user decide ElMaestro 2015-03-30 15:44
- to exclude or not to exclude - let the user decide yjlee168 2015-03-30 11:28
- to exclude or not to exclude - let the user decide mittyri 2015-03-29 19:04
- to exclude or not to exclude the subjects with bear? yjlee168 2015-03-28 21:03
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