Subjects in replicate BE study EU/FDA [RSABE / ABEL]
Dear Relaxation.
All the subjects with incomplete data in the EMA dataset I have at least one period with T and one with R. Thus they of course have a contribution to the evaluation of T-R and you will find differences if including or excluding them.
Seems here you are totally correct
.
❝ As a quick example (method A on the EMA dataset I (?, the 4 period one))
❝ Original result:
❝ 115.66 (107.11-124.97)
❝ Incomplete subjects excluded by hand:
❝ 115.46 (106.49-125.19)
❝ [no 11/20/24/31/42/67/69/71] --> no automatic excludion of incomplete data sets
All the subjects with incomplete data in the EMA dataset I have at least one period with T and one with R. Thus they of course have a contribution to the evaluation of T-R and you will find differences if including or excluding them.
❝ For the show, subject 100 with R twice with values of 1000 and 500 added:
❝ 112.21 (1.16-10833.43)
❝ --> even subjects without data for a T vs R comparison have an impact (choosing such values for ln(data) was a little bit too much but is nicely illustrating, isn't it).
Seems here you are totally correct

—
Regards,
Detlew
Regards,
Detlew
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