Bioequivalence and Bioavailability Forum

Beyond the abstract [Design Issues]

posted by Helmut  – Vienna, Austria, 2015-02-11 14:01 (4157 d 11:01 ago) – Posting: # 14402
Views: 16,475

Dear Detlew,

❝ [peer_review]

❝ "Abstract

❝ ... tablets in twenty-four healthy volunteers ..."

❝ [/peer_review]

[response_to_reviewer]

• Although the study was planned for 24 subjects, the paper states on p.88:
  • Two female volun­teers did not show up for the study due to personal issues; so two male volunteers were retired to keep pair sequences and com­plete sta­tis­ti­cal treatment; without affecting the final result after having per­form­ed the cor­res­ponding randomization test. Thus; the study was per­form­ed on twenty sub­jects.
  20 is also mentioned in Figure 2 and Tables 2&3 (p.89). Why two male sub­jects were “retired” (to keep balance?) – thus decreasing power – is beyond me.

[/response_to_reviewer]

❝ BTW: CI2CV() is the same function as CVfromCI() and was only "invented" because my brain was not able to remember which name was implemented by me.

Understandable. I always use CI2CV() as well.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Montelukast BE study rahul dixit 2011-01-03 15:17 [Design Issues] 
  • Montelukast BE study bjkim97 2011-01-06 06:45
    • Opinions ... d_labes 2011-01-07 13:51
      • Opinions ... bjkim97 2011-01-11 06:47
    • Montelukast BE study joy_fm 2015-02-05 13:10
      • MHRA’s PARs Helmut 2015-02-05 13:24
        • MHRA’s PARs joy_fm 2015-02-10 17:38
          • CV from the CI Helmut 2015-02-11 02:05
            • CI2CV d_labes 2015-02-11 09:16
              • Beyond the abstractHelmut 2015-02-11 13:01
                • Beyond the abstract ElMaestro 2015-02-11 13:36
                  • Beyond the abstract & Kinetica Helmut 2015-02-11 14:27
                    • Beyond the abstract & Kinetica d_labes 2015-02-11 14:59
                      • Partial credit ElMaestro 2015-02-11 15:49
                        • Partial credit ioanam 2016-01-22 14:17
                          • Partial credit ElMaestro 2016-01-22 14:58
                            • Partial credit Helmut 2016-01-22 15:06