S×F variance [General Statistics]
Hi Angus,
Of course the Concerta BE studies will not be RSABE based since the SwRs are all less than 0.294. So for partial AUCs + Cmax we will go through the ABE routine and conclude based on 80-125% CI. Then Helmut's suggestion above can be used to evaluate the 2nd criteria. The 2nd criteria (seems to me) is IBE/PBE based and I have no clue if you can get the info from the ABE routine. Personally I just don't see how one can fail the 2nd criteria (in my thinking) but then you have to demonstrate both... The 95% UCB I believe is for FDA to collect data, they probably want it for their own use.
Hope I answered your question.
P.S. I still don't understand the email you got from Ana regarding the computation of S2D from the G Matrix. If I recall correctly, she said to use the between subject variances of T & R + the between subject covariance for T & R???? See post
Happy Holidays!
John
Of course the Concerta BE studies will not be RSABE based since the SwRs are all less than 0.294. So for partial AUCs + Cmax we will go through the ABE routine and conclude based on 80-125% CI. Then Helmut's suggestion above can be used to evaluate the 2nd criteria. The 2nd criteria (seems to me) is IBE/PBE based and I have no clue if you can get the info from the ABE routine. Personally I just don't see how one can fail the 2nd criteria (in my thinking) but then you have to demonstrate both... The 95% UCB I believe is for FDA to collect data, they probably want it for their own use.
Hope I answered your question.
P.S. I still don't understand the email you got from Ana regarding the computation of S2D from the G Matrix. If I recall correctly, she said to use the between subject variances of T & R + the between subject covariance for T & R???? See post
Happy Holidays!
John
Complete thread:
- S×F variance Helmut 2014-12-23 15:32 [General Statistics]
- S×F variance AngusMcLean 2014-12-23 16:32
- S×F variance Helmut 2014-12-23 17:17
- S×F variance AngusMcLean 2014-12-28 23:12
- S×F variance Helmut 2014-12-23 17:17
- S×F variance AngusMcLean 2014-12-23 20:56
- S×F variance jag009 2014-12-23 23:07
- S×F variance AngusMcLean 2014-12-24 01:39
- S×F variancejag009 2014-12-24 16:21
- S×F variance AngusMcLean 2014-12-24 17:50
- S×F variancejag009 2014-12-24 16:21
- S×F variance AngusMcLean 2015-01-06 17:30
- S×F variance: Followup jag009 2015-01-08 22:42
- S×F variance: Followup AngusMcLean 2015-01-09 01:44
- S×F variance: Followup jag009 2015-01-12 16:53
- S×F variance: Followup AngusMcLean 2015-01-12 20:56
- S×F variance: 3rd opinion Helmut 2015-01-13 01:25
- S×F variance: 3rd opinion AngusMcLean 2015-01-13 20:13
- S×F variance: 3rd opinion AngusMcLean 2015-01-14 21:29
- S×F variance: 3rd opinion AngusMcLean 2015-01-29 23:38
- S×F variance: 3rd opinion Helmut 2015-01-13 01:25
- S×F variance: Followup AngusMcLean 2015-01-30 23:24
- S×F variance: Followup jag009 2015-02-02 16:31
- S×F variance: Followup AngusMcLean 2015-02-02 17:22
- S×F variance: Followup jag009 2015-02-05 18:14
- S×F variance: Followup AngusMcLean 2015-02-06 01:39
- S×F variance: Followup jag009 2015-02-06 17:13
- S×F variance: Followup AngusMcLean 2015-02-06 19:36
- S×F variance: Followup jag009 2015-02-17 22:49
- S×F variance: Followup AngusMcLean 2015-02-19 23:25
- S×F variance: Followup jag009 2015-02-21 21:08
- S×F variance: Followup AngusMcLean 2015-02-22 17:25
- S×F variance: Followup jag009 2015-02-23 16:58
- S×F variance: Followup AngusMcLean 2015-02-22 17:25
- S×F variance: Followup jag009 2015-02-21 21:08
- S×F variance: Followup AngusMcLean 2015-02-19 23:25
- S×F variance: Followup jag009 2015-02-17 22:49
- S×F variance: Followup AngusMcLean 2015-02-06 19:36
- S×F variance: Followup jag009 2015-02-05 18:14
- S×F variance: Followup AngusMcLean 2015-02-02 17:22
- S×F variance: Followup jag009 2015-02-02 16:31
- S×F variance: Followup AngusMcLean 2015-01-12 20:56
- S×F variance: Followup jag009 2015-01-12 16:53
- S×F variance: Followup AngusMcLean 2015-01-09 01:44
- S×F variance: Followup jag009 2015-01-08 22:42
- S×F variance AngusMcLean 2014-12-24 01:39
- S×F variance AngusMcLean 2015-01-06 18:48
- S×F variance jag009 2015-01-07 21:28
- S×F variance Helmut 2015-01-08 16:10
- S×F variance: Typo. jag009 2015-01-08 17:32
- S×F variance AngusMcLean 2015-01-08 18:51
- S×F variance jag009 2015-01-08 20:02
- S×F variance AngusMcLean 2015-01-08 20:27
- S×F variance jag009 2015-01-08 20:33
- S×F variance AngusMcLean 2015-01-08 20:27
- S×F variance jag009 2015-01-08 20:02
- S×F variance AngusMcLean 2015-01-08 18:51
- S×F variance: Typo. jag009 2015-01-08 17:32
- S×F variance Helmut 2015-01-08 16:10
- S×F variance jag009 2015-01-07 21:28
- S×F variance AngusMcLean 2014-12-23 16:32