Bioequivalence and Bioavailability Forum

S×F variance [General Statistics]

posted by Helmut – Vienna, Austria, 2014-12-23 16:32 (3405 d 08:28 ago) – Posting: # 14150
Views: 43,013

Dear all – or shall I rather say Angus & John?

Since the other thread (due to indenting of posts) becomes increasingly difficult to read I decided to close it. Please continue here.

Regrettably I had too little spare time to dive into. However, some points:

#14138: John is correct that the setup should essentially follow FDA’s code for RSABE. Therefore, anything obtained from ABE is not useful.
#14141: I developed the RSABE-workflow (see here) in the first place. We presented a poster at the AAPS Meeting in 2013 (download). Ana’s new templates removed the clumsy workaround for joining values of the χ², since chiinv(p, df) was introduced in PHX/WNL6.4 and can be used in the custom transformation (RSABE|Prepare Data for RSABE analysis|s2wr and dfd|Step 4).
@John: Note that these templates will not work in PHX/WNL6.3.
#14146: The template is for RSABE, therefore, variability of T is not included (which John correctly pointed out). Yes, it’s doable to add the coding for T.
#14147: The template covers the partial replicate as well. Still to do for the next version: A setup for the fully replicated two-sequence three-period (TRT|RTR) design which would avoid the convergence issues seen in ABE sometimes. BTW, I’ll submit a protocol with such a design to FDA’s OGD next month for review.
#14149: Modifying the ABE-part doesn’t do the job (see #1 above). What you could do: Copy the entire Prepare Data for RSABE analysis workflow and change the coding in the second one from R to T. Don’t forget to change all filters and transformations. Then you have both the results for R and T. Proceed from there.

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Helmut Schütz

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Complete thread:

S×F varianceHelmut 2014-12-23 15:32 [General Statistics]
- S×F variance AngusMcLean 2014-12-23 16:32
  - S×F variance Helmut 2014-12-23 17:17
    - S×F variance AngusMcLean 2014-12-28 23:12
- S×F variance AngusMcLean 2014-12-23 20:56
- S×F variance jag009 2014-12-23 23:07
  - S×F variance AngusMcLean 2014-12-24 01:39
    - S×F variance jag009 2014-12-24 16:21
      - S×F variance AngusMcLean 2014-12-24 17:50
  - S×F variance AngusMcLean 2015-01-06 17:30
    - S×F variance: Followup jag009 2015-01-08 22:42
      - S×F variance: Followup AngusMcLean 2015-01-09 01:44
        
        S×F variance: Followup jag009 2015-01-12 16:53
        
        S×F variance: Followup AngusMcLean 2015-01-12 20:56
        
        S×F variance: 3rd opinion Helmut 2015-01-13 01:25
        
        S×F variance: 3rd opinion AngusMcLean 2015-01-13 20:13
        S×F variance: 3rd opinion AngusMcLean 2015-01-14 21:29
        
        S×F variance: 3rd opinion jag009 2015-01-14 23:00
        
        α vs. 1–α Helmut 2015-01-15 00:54
        
        α vs. 1–α jag009 2015-01-15 22:38
        
        α vs. 1–α Helmut 2015-01-16 00:13
        
        α vs. 1–α jag009 2015-01-19 20:09
        
        α vs. 1–α jag009 2015-01-19 16:02
        
        S×F variance: 3rd opinion AngusMcLean 2015-01-29 23:38
        
        S×F variance: Followup AngusMcLean 2015-01-30 23:24
        
        S×F variance: Followup jag009 2015-02-02 16:31
        
        S×F variance: Followup AngusMcLean 2015-02-02 17:22
        
        S×F variance: Followup jag009 2015-02-05 18:14
        
        S×F variance: Followup AngusMcLean 2015-02-06 01:39
        
        S×F variance: Followup jag009 2015-02-06 17:13
        
        S×F variance: Followup AngusMcLean 2015-02-06 19:36
        
        S×F variance: Followup jag009 2015-02-17 22:49
        
        S×F variance: Followup AngusMcLean 2015-02-19 23:25
        
        S×F variance: Followup jag009 2015-02-21 21:08
        
        S×F variance: Followup AngusMcLean 2015-02-22 17:25
        
        S×F variance: Followup jag009 2015-02-23 16:58
- S×F variance AngusMcLean 2015-01-06 18:48
  - S×F variance jag009 2015-01-07 21:28
    - S×F variance Helmut 2015-01-08 16:10
      - S×F variance: Typo. jag009 2015-01-08 17:32
        
        S×F variance AngusMcLean 2015-01-08 18:51
        
        S×F variance jag009 2015-01-08 20:02
        
        S×F variance AngusMcLean 2015-01-08 20:27
        
        S×F variance jag009 2015-01-08 20:33

S×F vari­­ance [General Sta­tis­tics]

Complete thread:

S×F variance [General Statistics]