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RegisterSmoking [Design Issues]
posted by Helmut 
– Vienna, Austria, 2014-12-17 18:48 (4212 d 01:16 ago) – Posting: # 14097
Views: 16,255
Dear Ohlbe,
Absolutely (GI transit time may increase). Either include only non-smokers (confirmed by cotinine tests) or allow (moderate) smokers to smoke.
In the latter case a dedicated area is a must (check that smokers don’t exceed the daily allowance stated in the protocol). If the clinical site doesn’t have a smoking area, include only non-smokers. Sending smokers to the street and exposing them to demanding climatic conditions (winter in Moscow or Saskatoon easily –40 ℃; summer-monsoon in India) is not an alternative.
But again: In a crossover whatever one has chosen shouldn’t matter. I would not suggest that smokers refrain from smoking during hospitalization. Their craving symptoms might even annoy other volunteers and the clinical staff.
❝ Helmut, couldn't a sudden smoking cessation also influence the gastrointestinal motility, or sumfink like this ?
Absolutely (GI transit time may increase). Either include only non-smokers (confirmed by cotinine tests) or allow (moderate) smokers to smoke.
In the latter case a dedicated area is a must (check that smokers don’t exceed the daily allowance stated in the protocol). If the clinical site doesn’t have a smoking area, include only non-smokers. Sending smokers to the street and exposing them to demanding climatic conditions (winter in Moscow or Saskatoon easily –40 ℃; summer-monsoon in India) is not an alternative.
But again: In a crossover whatever one has chosen shouldn’t matter. I would not suggest that smokers refrain from smoking during hospitalization. Their craving symptoms might even annoy other volunteers and the clinical staff.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- BE study inclusion & exclusion criteria cher0424 2014-12-16 01:30 [Design Issues]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- BE study inclusion & exclusion criteria Helmut 2014-12-16 14:53
- BE study inclusion & exclusion criteria Ohlbe 2014-12-16 17:29
- BE study inclusion & exclusion criteria cher0424 2014-12-17 02:19
- Drugs of abuse Helmut 2014-12-17 14:42
- Drugs of abuse cher0424 2014-12-18 04:54
- Stick to the protocol, but… Helmut 2014-12-18 14:02
- Drugs of abuse cher0424 2014-12-18 04:54
- Drugs of abuse Helmut 2014-12-17 14:42
- BE study inclusion & exclusion criteria Helmut 2014-12-17 13:33
- BE study inclusion & exclusion criteria cher0424 2014-12-17 02:19
- BE study inclusion & exclusion criteria cher0424 2014-12-17 02:02
- BE study inclusion & exclusion criteria Helmut 2014-12-17 14:24
- BE study inclusion & exclusion criteria Ohlbe 2014-12-16 17:29
- BE study inclusion & exclusion criteria Ohlbe 2014-12-17 17:35
- BE study inclusion & exclusion criteria Helmut 2014-12-16 14:53
Ing. Helmut Schütz