Bioequivalence and Bioavailability Forum

Update: S×F variance test [Regulatives / Guidelines]

posted by AngusMcLean – USA, 2014-12-09 18:47 (3423 d 00:34 ago) – Posting: # 14038
Views: 11,889

From above message the output 4 period replicate FDA template is repeated as follows:

Dependent Parameter Estimate
ln Cmax lambda(1,1)_11 is 0.82840679
ln Cmax lambda(1,2)_11 is 0.85299475
ln Cmax lambda(2,2)_11 is 5.63E-07
ln Cmax Var(Period*Formulation*Subject)_21 is 0.11739425
ln Cmax Var(Period*Formulation*Subject)_22 is 0.20211805

From Ana’s message the value for subj. formulation interaction(sig_D^2) is as follows:

(0.82840679)+(5.63E-07)-2*(0.85299475)= -0.87758

Here are my results from the same data set in Phoenix: my input structure is different
Data lambda(1,1)_11 0.85299471
Data lambda(1,2)_11 0.82840678
Data lambda(2,2)_11 8.34E-07
Data Var(Period*Formulation*Subject)_21 0.20211811
Data Var(Period*Formulation*Subject)_22 0.11739421

I used BABA for the input for the first subject. If you look at the Parameter Key and Group Levels on the Parameter Key Output Workbook in Phoenix I have first output parameter as reference not test. That is why there is transposition in the parameter values.

Thread locked

Complete thread:

Concerta Guidance: Sub x Form interaction variance test jag009 2014-12-05 20:57 [Regulatives / Guidelines]
- Concerta Guidance: Sub x Form interaction variance test AngusMcLean 2014-12-06 01:28
  - Concerta Guidance: Sub x Form interaction variance test Helmut 2014-12-06 01:53
    - Concerta Guidance: Sub x Form interaction variance test jag009 2014-12-07 20:58
      - Concerta Guidance: S×F variance test AngusMcLean 2014-12-08 01:35
        
        Concerta Guidance: S×F variance test Helmut 2014-12-08 14:12
        
        Update: S×F variance test jag009 2014-12-08 17:40
        
        Update: S×F variance test AngusMcLean 2014-12-08 18:09
        
        EMA’s dataset I Helmut 2014-12-08 18:18
        
        EMA’s dataset I AngusMcLean 2014-12-08 19:55
        
        Update: S×F variance test jag009 2014-12-08 20:41
        
        Update: S×F variance test AngusMcLean 2014-12-08 18:18
        
        Question jag009 2014-12-10 17:01
        
        Question AngusMcLean 2014-12-10 18:34
        
        Update: S×F variance test kumarnaidu 2014-12-09 06:48
        
        Update: S×F variance test jag009 2014-12-09 15:16
        
        Update: S×F variance testAngusMcLean 2014-12-09 17:47
        
        Update: S×F variance test jag009 2014-12-09 18:01
        
        Update: S×F variance test AngusMcLean 2014-12-09 18:30
        
        Update: S×F variance test jag009 2014-12-18 15:31
        
        Update: S×F variance test AngusMcLean 2014-12-18 16:12
        
        Update: S×F variance test jag009 2014-12-22 17:28
        
        Update: S×F variance test AngusMcLean 2014-12-22 19:32
        
        Update: S×F variance test jag009 2014-12-22 20:19
        
        Update: S×F variance AngusMcLean 2014-12-22 20:45
        
        Update: S×F variance jag009 2014-12-22 20:51
        
        Update: S×F variance AngusMcLean 2014-12-22 21:10
        Update: S×F variance AngusMcLean 2014-12-22 21:36
        
        Update: S×F variance jag009 2014-12-22 22:18
        
        Update: S×F variance AngusMcLean 2014-12-22 23:26
        
        Update: S×F variance jag009 2014-12-23 04:43
        
        Update: S×F variance AngusMcLean 2014-12-23 15:24
        
        Update: S×F variance test AngusMcLean 2014-12-09 21:03
        
        Coding Helmut 2014-12-09 18:49
        
        working.... jag009 2014-12-09 22:24
- Concerta Guidance: S×F variance test ElMaestro 2014-12-06 11:12
  - Concerta Guidance: S×F variance test AngusMcLean 2014-12-07 14:32
    - Concerta Guidance: S×F variance test ElMaestro 2014-12-07 18:08
      - Concerta Guidance: S×F variance test AngusMcLean 2014-12-07 23:13
        
        Concerta Guidance: S×F variance test ElMaestro 2014-12-08 12:25
        
        Concerta Guidance: S×F variance test nobody 2014-12-08 13:44
        Concerta Guidance: S×F variance test AngusMcLean 2014-12-08 14:03
        
        Concerta Guidance:S×F variance test nobody 2014-12-08 14:32

Update: S×F vari­­ance test [Regulatives / Guidelines]

Complete thread:

Update: S×F variance test [Regulatives / Guidelines]