Bioequivalence and Bioavailability Forum • Difficulties with NCA BEAR

Difficulties with NCA BEAR [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2014-11-22 04:21 (4228 d 21:42 ago) – Posting: # 13912
Views: 20,395

Dear PK_Lover,

Do you use the default setting to analyze your data? I think the error is due to failure to find a lambda_z during NCA (invalid 'y' when doing linear regression). If the error still persists, please check your data carefully. Or try to switch lambda_z estimation method to 'Select 2-6 data points manually' (lambda_z estimation = 5) instead of using the default of 'Adjusted R sq. (ARS).' By the way, manual data point selection may also provide you a chance to check subjects' data individually. Hope this can help.

❝ [...]

❝ And I am using data from a simple Crossover design with 2 periods, single administration.

—
All the best,
-- Yung-jin Lee
bear v2.9.6:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

Difficulties with NCA BEAR PK_Lover 2014-11-21 00:28 [🇷 for BE/BA]
- Difficulties with NCA BEAR yjlee168 2014-11-21 07:34
  - Difficulties with NCA BEAR PK_Lover 2014-11-22 00:07
    - Difficulties with NCA BEARyjlee168 2014-11-22 03:21
      - Difficulties with NCA BEAR PK_Lover 2014-11-22 09:47
        
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        old bear and friends yjlee168 2016-09-16 09:42
        
        old bear and friends VStus 2016-09-26 13:30
        
        multiple-dosed study with bear yjlee168 2016-09-26 18:04
        
        multiple-dosed study with bear VStus 2016-10-11 09:01
        
        multiple-dosed study with bear yjlee168 2016-10-11 10:15
        
        multiple-dosed study with bear VStus 2016-10-11 10:37
        multiple-dosed study with bear VStus 2016-10-12 10:37
        
        multiple-dosed study with bear [solved] yjlee168 2016-10-12 18:42