Difficulties with NCA BEAR [🇷 for BE/BA]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2014-11-21 08:34 (3415 d 22:46 ago) – Posting: # 13898
Views: 16,425

(edited by yjlee168 on 2014-11-21 11:05)

Dear PK_Lover,

Could you post the setting content from R console here after running 'go()' at the beginning? Something like:

 -------------------  Current settings ------------------

                 Methods Setting                  which_is
1              run demo?       1                       yes
2          study design?       0           2x2x2 crossover
3  single-/multiple-dose       0               single-dose
4      lambda_z estimate       0          adj. R sq. (ARS)
5        trapezoidal AUC       0        linear-up/log-down
6      BE criterion (LL)      80               lower limit
7                   ODA?       0                        no
8                  dose?  100000                dose given
9        dosing interval      24       *multiple-dose only
10                 Tlast     120       *multiple-dose only
11                 pAUC?       0                   all AUC
12            pAUC_start     121 the starting time of pAUC
13              pAUC_end     128      the end time of pAUC
14           IDP output?       0                        no

 The plot label of x-axis -> Time after Dosing (hr)
  and the label of y-axis -> DrugX Plasma Conc. (ng/mL)
 --------------------------------------------------------
...

Is your analysis using the partial or truncated AUC (pAUC) with multiple-dosed? If yes, please make sure that pAUC_start and pAUC_end should count from the time of starting dose (i.e., time = 0.), not within one dosing interval. If not, please turn pAUC off (= 0). Sorry about this error.

❝ [...]

❝ I ran BEAR, import the file, the values appear correctly in the table. It starts the analysis, it shows some pk values but then states:


Error in lm.fit(x, y, offset = offset, singular.ok = singular.ok, ...) :

❝ NA/NaN/Inf in 'y'


❝ and crashes. I have checked all the data, seems ok.

❝ [...]


All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

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