Bioequivalence and Bioavailability Forum • Difficulties with NCA BEAR

Difficulties with NCA BEAR [🇷 for BE/BA]

posted by yjlee168 – Kaohsiung, Taiwan, 2014-11-21 08:34 (3809 d 11:10 ago) – Posting: # 13898
Views: 17,877
(edited on 2014-11-21 11:05)

Dear PK_Lover,

Could you post the setting content from R console here after running 'go()' at the beginning? Something like:


 -------------------  Current settings ------------------



                 Methods Setting                  which_is

1              run demo?       1                       yes

2          study design?       0           2x2x2 crossover

3  single-/multiple-dose       0               single-dose

4      lambda_z estimate       0          adj. R sq. (ARS)

5        trapezoidal AUC       0        linear-up/log-down

6      BE criterion (LL)      80               lower limit

7                   ODA?       0                        no

8                  dose?  100000                dose given

9        dosing interval      24       *multiple-dose only

10                 Tlast     120       *multiple-dose only

11                 pAUC?       0                   all AUC

12            pAUC_start     121 the starting time of pAUC

13              pAUC_end     128      the end time of pAUC

14           IDP output?       0                        no



 The plot label of x-axis -> Time after Dosing (hr) 

  and the label of y-axis -> DrugX Plasma Conc. (ng/mL)

 --------------------------------------------------------

...

Is your analysis using the partial or truncated AUC (pAUC) with multiple-dosed? If yes, please make sure that pAUC_start and pAUC_end should count from the time of starting dose (i.e., time = 0.), not within one dosing interval. If not, please turn pAUC off (= 0). Sorry about this error.

❝ [...]

❝ I ran BEAR, import the file, the values appear correctly in the table. It starts the analysis, it shows some pk values but then states:

❝

❝ Error in lm.fit(x, y, offset = offset, singular.ok = singular.ok, ...) :

❝ NA/NaN/Inf in 'y'

❝

❝ and crashes. I have checked all the data, seems ok.

❝ [...]

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

Difficulties with NCA BEAR PK_Lover 2014-11-21 00:28 [🇷 for BE/BA]
- Difficulties with NCA BEARyjlee168 2014-11-21 07:34
  - Difficulties with NCA BEAR PK_Lover 2014-11-22 00:07
    - Difficulties with NCA BEAR yjlee168 2014-11-22 03:21
      - Difficulties with NCA BEAR PK_Lover 2014-11-22 09:47
        
        help test NCA BEAR yjlee168 2014-12-01 08:13
        
        help test NCA BEAR Emrah Soner Özdeş 2015-01-15 14:37
        
        help test NCA BEAR Jam 2015-01-23 08:55
        
        CSV files with a comma at the end of each line? yjlee168 2015-01-25 04:35
      - Difficulties with NCA BEAR xtianbadillo 2016-09-15 22:44
        
        old bear and friends yjlee168 2016-09-16 09:42
        
        old bear and friends VStus 2016-09-26 13:30
        
        multiple-dosed study with bear yjlee168 2016-09-26 18:04
        
        multiple-dosed study with bear VStus 2016-10-11 09:01
        
        multiple-dosed study with bear yjlee168 2016-10-11 10:15
        
        multiple-dosed study with bear VStus 2016-10-11 10:37
        multiple-dosed study with bear VStus 2016-10-12 10:37
        
        multiple-dosed study with bear [solved] yjlee168 2016-10-12 18:42