Star Trek: The Next Generation [Software]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2014-10-09 13:06 (3863 d 05:59 ago) – Posting: # 13675
Views: 38,971

Dear Helmut,

Have you ever tried to add/change options of MAXITER (default is only 50; may consider to increase this value) and / or MAXFUNC (default is 150) with PROC MIXED when getting convergence failure for ABE? I did that with lme() in bear recently for dataset that failed to converge using the default number of iterations. It solved the problem of convergence failure. The function optimization of PROC MIXED is the Newton-Raphson algorithm. I don't know if it works or not with PROC MIXED.

❝ [...]


FDA

❝      ABE

❝          FA0(2): according to the guidance; sometimes a warning, sometimes no convergence

❝          CSH: suggested as an alternative in the guidance; fails to converge sometimes as well [...]


❝          FA0(1): no problems with convergence in all datasets we have tested so far [...]


All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,669 registered users;
204 visitors (0 registered, 204 guests [including 5 identified bots]).
Forum time: 19:05 CEST (Europe/Vienna)

[Those] who have an excessive faith in their theories or in their
ideas are not only poorly disposed to make discoveries, but they
also make very poor observations.    Claude Bernard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5