Calculation of intra-subject CVs in replicate design [General Sta­tis­tics]

posted by Dr Andrew Leary – Ireland, 2007-12-05 17:35 (6064 d 22:50 ago) – Posting: # 1356
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Hello Helmut

Any word on the query (in red) below?

Kind regards

Andrew Leary


My question is how to calculate intrasubject CV's for a 4-period 2-treatment replicate bioequivalence trial which I intend to analyze using proc mixed (SAS). I have analysed crossover bioequivalence trials before and used the formula 100%(e^MSE-1)^0.5 to calculate itrasubject CV where MSE is the mean square error. MSE was claculated using proc glm. How should I calculate MSE this time? Do I calculate two separate ANOVA models for each treatment and use the different MSE's from each analysis to give separate intra-subject CV's or do I take a completly different approach?


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