Bioequivalence and Bioavailability Forum

LSM limbo [General Statistics]

posted by Ohlbe – France, 2014-07-31 11:47 (3551 d 00:28 ago) – Posting: # 13323
Views: 22,644

Dear Helmut,

❝ Manually? Never done that. :-D

❝ It’s a complete mess. Subjects with incomplete data are excluded from the estimation of σ²_WR, but kept in the calculation of the upper 95% boundary (FDA) or excluded for the calculation of the 90% CI (EMA, all fixed effects. A mixed-effects model is not acceptable for EMA).

I would not think for even a split second of trying to recalculate manually the 90 % CI or σ²_WR... But I was hoping there would be a simple way to at least recalculate LSMs (or to understand how they are calculated).

Thanks anyway !

—
Regards
Ohlbe

Complete thread:

Confidence Interval for Transformed data Unbalanced study usfda_emea 2007-03-06 14:39 [General Statistics]
- CI for Transformed data Unbalanced study Helmut 2007-03-06 16:46
  - CI for Transformed data Unbalanced study drshiv 2007-03-06 18:49
  - CI for Transformed data Unbalanced study usfda_emea 2007-03-07 06:21
    - CI for Transformed data Unbalanced study Helmut 2007-03-07 12:04
      - CI for Transformed data Unbalanced study usfda_emea 2007-03-07 12:34
      - CI for Transformed data Unbalanced study Ohlbe 2014-07-30 15:04
        
        LSM limbo Helmut 2014-07-31 02:54
        
        LSM limboOhlbe 2014-07-31 09:47
        90% CI limbo VStus 2017-03-01 14:07
        
        RSABE ⇒ ABEL Helmut 2017-03-03 13:34
        
        RSABE ⇒ ABEL VStus 2017-03-03 15:31
        
        s2wR != mse, FDA != EMA d_labes 2017-03-04 14:49
        
        s2wR != mse, FDA != EMA ElMaestro 2017-03-04 19:13
        
        s2wR from ISC in FDA approach d_labes 2017-03-05 12:18
        
        s2wR from ISC in FDA approach ElMaestro 2017-03-05 13:50
        
        s2wR != mse, FDA != EMA VStus 2017-03-04 21:41
        
        s2wR != mse, FDA != EMA Helmut 2017-03-06 13:40

LSM limbo [General Sta­tis­tics]

Complete thread:

LSM limbo [General Statistics]