Bioequivalence and Bioavailability Forum

CI for Transformed data Unbalanced study [General Statistics]

posted by Ohlbe – France, 2014-07-30 17:04 (3934 d 13:21 ago) – Posting: # 13319
Views: 24,761

Dear Helmut,

❝ ❝ Can you help me with the formula for LSM (I wish to do a manual calculation, for verification purposes) and a brief explaination about why this method is used for unbalanced study?

❝

❝ The calculation is not different from a balanced study.

❝

❝ I’ll give you an example for the reference [...]

How do you calculate the LSM in a full replicate design study (RTRT and TRTR, with some subjects missing here and there) ?

—
Regards
Ohlbe

Complete thread:

Confidence Interval for Transformed data Unbalanced study usfda_emea 2007-03-06 14:39 [General Statistics]
- CI for Transformed data Unbalanced study Helmut 2007-03-06 16:46
  - CI for Transformed data Unbalanced study drshiv 2007-03-06 18:49
  - CI for Transformed data Unbalanced study usfda_emea 2007-03-07 06:21
    - CI for Transformed data Unbalanced study Helmut 2007-03-07 12:04
      - CI for Transformed data Unbalanced study usfda_emea 2007-03-07 12:34
      - CI for Transformed data Unbalanced studyOhlbe 2014-07-30 15:04
        
        LSM limbo Helmut 2014-07-31 02:54
        
        LSM limbo Ohlbe 2014-07-31 09:47
        90% CI limbo VStus 2017-03-01 14:07
        
        RSABE ⇒ ABEL Helmut 2017-03-03 13:34
        
        RSABE ⇒ ABEL VStus 2017-03-03 15:31
        
        s2wR != mse, FDA != EMA d_labes 2017-03-04 14:49
        
        s2wR != mse, FDA != EMA ElMaestro 2017-03-04 19:13
        
        s2wR from ISC in FDA approach d_labes 2017-03-05 12:18
        
        s2wR from ISC in FDA approach ElMaestro 2017-03-05 13:50
        
        s2wR != mse, FDA != EMA VStus 2017-03-04 21:41
        
        s2wR != mse, FDA != EMA Helmut 2017-03-06 13:40

CI for Transformed data Unbalanced study [General Sta­tis­tics]

Complete thread:

CI for Transformed data Unbalanced study [General Statistics]