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Register156 ? [Study Assessment]
Dear unique_one.
Simple enough using PowerTOST:
Approach: The Believer’s ("Carved in stone")
Approach: The Conservative’s
Thus a relative conservative estimate (more conservative assumptions about CV and GMR are imaginable) of sample size would be 156. Seldom seen such a high sample size in BE studies.
❝ Could you please let me know that what could be in approx sample size if study is repeated?
Simple enough using PowerTOST:
Approach: The Believer’s ("Carved in stone")
AUC
sampleN.TOST(CV=0.273, theta0=1.122, print=F)
Design alpha CV theta0 theta1 theta2 Sample size Achieved power Target power
1 2x2 0.05 0.273 1.122 0.8 1.25 78 0.802053 0.8
Cmax
sampleN.TOST(CV=0.282, theta0=1.095, print=F)
Design alpha CV theta0 theta1 theta2 Sample size Achieved power Target power
1 2x2 0.05 0.282 1.095 0.8 1.25 56 0.8039018 0.8Approach: The Conservative’s
AUC
sampleN.TOST(CV=0.3, theta0=1.15, print=F)
Design alpha CV theta0 theta1 theta2 Sample size Achieved power Target power
1 2x2 0.05 0.3 1.15 0.8 1.25 156 0.8030697 0.8
Cmax
sampleN.TOST(CV=0.3, theta0=1.1, print=F)
Design alpha CV theta0 theta1 theta2 Sample size Achieved power Target power
1 2x2 0.05 0.3 1.1 0.8 1.25 68 0.8073325 0.8Thus a relative conservative estimate (more conservative assumptions about CV and GMR are imaginable) of sample size would be 156. Seldom seen such a high sample size in BE studies.
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Results Analysis unique_one 2014-07-08 08:58 [Study Assessment]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
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- The smaller a study, the more uncertain its results unique_one 2014-07-09 06:59
- The smaller a study, the more uncertain its results unique_one 2014-07-10 07:09
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- The smaller a study, the more uncertain its results Helmut 2014-07-08 17:39
- Don’t hurry; explore consequences unique_one 2014-07-08 14:01
- 156 ?d_labes 2014-07-08 12:03
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- Bootstrapping BE: Desultory thoughts Helmut 2021-07-09 14:50
- Bootstrapping BE: An attempt in 🇷 ElMaestro 2021-07-09 14:15
- Bootstrapping BE: An attempt in 🇷 Helmut 2021-07-08 13:50
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Ing. Helmut Schütz