Bioequivalence and Bioavailability Forum • Group effect commonly not relevant

Group effect commonly not relevant [Software]

posted by AngusMcLean – USA, 2014-07-07 00:52 (4359 d 02:42 ago) – Posting: # 13222
Views: 30,588

Hello Helmut: Yes; I did see that Formulation not Treatment later after lunch, but it still did not work. Then following your direction about Group being a classification variable (and including subject in model) I did get it to work.

Dependent hyothesis     NumDF Denomin     Fstat       p value

Ln(AUC)   int               1   64    11226.673       0

Ln(AUC)   Group             1   64        0.006028186 0.93835554

Ln(AUC)   Sequence          1   64        3.4513852   0.067800018

Ln(AUC)   Group*Sequence    1   64        0.000321727 0.9857451

Ln(AUC)   Group*Period      2   64        0.064946799 0.937179

Ln(AUC)   Formulation       1   64        0.36503556  0.54785867


Ln(AUC)   Formulation*Group 1   64        0.002630007 0.95925927

The formulation by group interaction p value was 0.95 for this composed data set.

Many thanks and also your sample size program in R works well: I have almost zero experience in R, but the reference you provided was easy to follow.

Here is the setup I used in Phoenix: Subject has to be mapped to get it to work (see link below)
http://screencast.com/t/EpJVIvdBr

Angus

Edit: BBCoded and a later post merged. [Helmut]

Complete thread:

Phoenix WNL to handle 2x2 crossover study with multip group zan 2014-06-27 23:29 [Software]
- Phoenix WNL to handle 2x2 crossover study with multip group ElMaestro 2014-06-28 23:23
- Group effect commonly not relevant Helmut 2014-06-30 16:55
  - Group effect in 2x2 BE study zan 2014-06-30 19:18
    - Group effect in 2x2 BE study ElMaestro 2014-06-30 20:36
    - To pool or not to pool Helmut 2014-06-30 20:51
      - To pool or not to pool zan 2014-06-30 21:02
        
        To pool or not to pool Helmut 2014-06-30 21:38
        
        To pool or not to pool zan 2014-06-30 21:46
        
        To pool or not to pool Helmut 2014-06-30 22:22
        
        To pool or not to pool zan 2014-07-01 01:15
        
        Partial vs. sequential tests in WNL Helmut 2014-07-01 12:26
        
        Partial vs. sequential tests in WNL zan 2014-07-01 18:03
        
        Loosing patience Helmut 2014-07-01 18:23
        
        To pool or not to pool ElMaestro 2014-06-30 22:11
        
        To pool or not to pool zan 2014-07-01 01:18
        To pool or not to pool zan 2014-07-02 19:56
        
        To pool or not to pool ElMaestro 2014-07-03 00:17
        
        To pool or not to pool zan 2014-07-03 00:36
        
        sequence- / period effect #666 Helmut 2014-07-03 10:05
  - Group effect commonly not relevant AngusMcLean 2014-07-06 16:19
    - Group effect commonly not relevant Helmut 2014-07-06 20:32
      - Group effect commonly not relevantAngusMcLean 2014-07-06 22:52
        
        Group effect commonly not relevant Helmut 2014-07-06 23:57
        
        PHX: Parameter mapping AngusMcLean 2014-07-07 15:04
        
        PHX: Parameter mapping Helmut 2014-07-07 15:45
        
        PHX: Parameter mapping Shuanghe 2014-07-07 17:35
        
        Great hint! Helmut 2014-07-07 17:54
        PHX: Parameter mapping AngusMcLean 2014-07-07 20:49
        
        PHX: Parameter mapping AngusMcLean 2014-07-07 18:46