at least 3 formulations for IVIVC [Dissolution / BCS / IVIVC]

posted by Helmut Homepage – Vienna, Austria, 2007-11-21 16:25 (5995 d 04:26 ago) – Posting: # 1317
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Dear Nirali,

❝ I have WinNOnlin 5.2 version with IVIVC kit.


How much did the IVIVC Toolkit cost?

❝ For IVIVC comparison WinNonlin ask minimum three formulation for comparison.


You will need at least 3 data pairs for any type of linear dependency; this is not a WinNonlin-problem.
Just imagine:
In a linear regression you estimate two parameters – intercept and slope.
With 3 data pairs, you have 1 degree of freedom left.
With only 2 data pairs you have no degrees of freedom, or in other words you will always be able to draw a straight line, but getting no information on goodness of fit (coefficient of correlation = exactly one).

I have only two formulation on hand :-( !


Oh, that’s bad – no resolution possible, unless you come up with results from a 3rd formulation…

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