Bioequivalence and Bioavailability Forum • at least 3 formulations for IVIVC

at least 3 formulations for IVIVC [Dissolution / BCS / IVIVC]

posted by Helmut – Vienna, Austria, 2007-11-21 16:25 (6795 d 08:11 ago) – Posting: # 1317
Views: 50,288

Dear Nirali,

❝ I have WinNOnlin 5.2 version with IVIVC kit.

How much did the IVIVC Toolkit cost?

❝ For IVIVC comparison WinNonlin ask minimum three formulation for comparison.

You will need at least 3 data pairs for any type of linear dependency; this is not a WinNonlin-problem.
Just imagine:
In a linear regression you estimate two parameters – intercept and slope.
With 3 data pairs, you have 1 degree of freedom left.
With only 2 data pairs you have no degrees of freedom, or in other words you will always be able to draw a straight line, but getting no information on goodness of fit (coefficient of correlation = exactly one).

❝ I have only two formulation on hand !

Oh, that’s bad – no resolution possible, unless you come up with results from a 3^rd formulation…

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Helmut Schütz

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Complete thread:

IVIVC Studies MGR 2007-02-02 10:10 [Dissolution / BCS / IVIVC]
- IVIVC Studies Helmut 2007-02-07 19:56
  - IVIVC Studies venu 2007-02-23 06:58
    - IVIVC Studies Dipesh Jayswal 2007-03-16 07:53
      - Wagner-Nelson, Loo-Riegelman Helmut 2007-03-16 15:39
        
        Wagner-Nelson, Loo-Riegelman Dipesh Jayswal 2007-03-19 10:04
        Deconvolution drcampos 2007-03-19 15:26
        
        Numerical Deconvolution Helmut 2007-03-19 16:20
        
        Numerical Deconvolution drcampos 2007-03-19 21:17
        Numerical Deconvolution Rayhope 2021-10-07 14:25
        
        Daniel still active in the Forum? Helmut 2021-10-07 16:38
        
        Daniel still active in the Forum? Rayhope 2021-10-08 09:07
        
        Daniel still active in the Forum? Rayhope 2021-11-11 08:35
        
        Wagner-Nelson Dipesh Jayswal 2007-03-21 08:21
        
        Wagner-Nelson Helmut 2007-03-21 12:13
        
        IVIVC jesse08 2007-09-01 01:38
        
        IVIVC / Mapping Helmut 2007-09-01 14:49
        
        IVIVC / Mapping jesse08 2007-09-02 00:32
        
        IVIVC / Software Helmut 2007-09-02 12:03
        
        IVIVC / Software jesse08 2007-10-03 02:13
        
        IVIVC / Software Nirali 2007-11-21 12:38
        
        at least 3 formulations for IVIVCHelmut 2007-11-21 15:25
        
        at least 3 formulations for IVIVC Nirali 2007-11-22 07:53
        
        at least 1 formulation for Level A Helmut 2007-11-22 09:53
        
        at least 1 formulation for Level A Nirali 2007-11-27 06:05
        
        IVIVC / Software SDavis 2009-09-25 09:11
        
        IVIVC set up/ requirements sonu 2009-09-23 08:47