Bioequivalence and Bioavailability Forum • Phoenix WNL to handle 2x2 crossover study with multip group

Phoenix WNL to handle 2x2 crossover study with multip group [Software]

posted by ElMaestro – Denmark, 2014-06-29 01:23 (4375 d 13:11 ago) – Posting: # 13166
Views: 31,222

Hello Zan,

I don't speak WNL but:

❝ 1. is it acceptable to just assign 4 periods to the 4 dosing days? If so,

❝ In the model specification: Treatment+Sequence+Period

❝ and in the variance structure--Random effect: Subject(Sequence).

That would be a little untraditional with four period levels. But it can be done and it is a little like working with period in group. What's the title of your study? (If it is something like "A two-treatment, two-period, two-sequence bioequivalence study blah blah" then you almost have the answer right there).

❝ 2. Can we still keep these 2 periods and add a Group term to these subjects (eg. Group 1 and Group 2)?. If so, in the model specification:

❝ Treatment+Sequence+Period+Group

Yes, much better, this is what I would do.

❝ but in the variance structure, I dont know what is appropriate to be added in the Random effect field. Should it be Subject(Sequence*Group).

Oh here we go again: Depending on your data listing you can probably just write Subject.

—
Pass or fail!
ElMaestro

Complete thread:

Phoenix WNL to handle 2x2 crossover study with multip group zan 2014-06-27 23:29 [Software]
- Phoenix WNL to handle 2x2 crossover study with multip groupElMaestro 2014-06-28 23:23
- Group effect commonly not relevant Helmut 2014-06-30 16:55
  - Group effect in 2x2 BE study zan 2014-06-30 19:18
    - Group effect in 2x2 BE study ElMaestro 2014-06-30 20:36
    - To pool or not to pool Helmut 2014-06-30 20:51
      - To pool or not to pool zan 2014-06-30 21:02
        
        To pool or not to pool Helmut 2014-06-30 21:38
        
        To pool or not to pool zan 2014-06-30 21:46
        
        To pool or not to pool Helmut 2014-06-30 22:22
        
        To pool or not to pool zan 2014-07-01 01:15
        
        Partial vs. sequential tests in WNL Helmut 2014-07-01 12:26
        
        Partial vs. sequential tests in WNL zan 2014-07-01 18:03
        
        Loosing patience Helmut 2014-07-01 18:23
        
        To pool or not to pool ElMaestro 2014-06-30 22:11
        
        To pool or not to pool zan 2014-07-01 01:18
        To pool or not to pool zan 2014-07-02 19:56
        
        To pool or not to pool ElMaestro 2014-07-03 00:17
        
        To pool or not to pool zan 2014-07-03 00:36
        
        sequence- / period effect #666 Helmut 2014-07-03 10:05
  - Group effect commonly not relevant AngusMcLean 2014-07-06 16:19
    - Group effect commonly not relevant Helmut 2014-07-06 20:32
      - Group effect commonly not relevant AngusMcLean 2014-07-06 22:52
        
        Group effect commonly not relevant Helmut 2014-07-06 23:57
        
        PHX: Parameter mapping AngusMcLean 2014-07-07 15:04
        
        PHX: Parameter mapping Helmut 2014-07-07 15:45
        
        PHX: Parameter mapping Shuanghe 2014-07-07 17:35
        
        Great hint! Helmut 2014-07-07 17:54
        PHX: Parameter mapping AngusMcLean 2014-07-07 20:49
        
        PHX: Parameter mapping AngusMcLean 2014-07-07 18:46