Calculation of intra-subject CVs in replicate design [General Sta­tis­tics]

posted by Dr Andrew Leary – Ireland, 2007-11-20 15:50 (5942 d 02:04 ago) – Posting: # 1312
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Dear Helmut

I hope that Berlin went well. I contacted you directly earlier this year with a question about the replicate design. You will be glad to see that this time I've used the Forum as requested!

My statistician has the following question:
My question is how to calculate intrasubject CV's for a 4-period 2-treatment replicate bioequivalence trial which I intend to analyze using proc mixed (SAS). I have analysed crossover bioequivalence trials before and used the formula 100%(e^MSE-1)^0.5 to calculate itrasubject CV where MSE is the mean square error. MSE was claculated using proc glm. How should I calculate MSE this time? Do I calculate two separate ANOVA models for each treatment and use the different MSE's from each analysis to give separate intra-subject CV's or do I take a completly different approach?

I hope that you can help.

Kind regards

Dr Andrew Leary
[Shandon Clinic, Cork, IRELAND]

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a research question, no matter how careful the subsequent
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