Bioequivalence and Bioavailability Forum • compromise

compromise [Bioanalytics]

posted by ElMaestro – Denmark, 2014-06-18 19:43 (3997 d 04:49 ago) – Posting: # 13085
Views: 14,401

Hi Helmut, Nobody,

let me offer a compromise that will satisfy you both as well as regulators:

If you are using evenly spaced calibrators (at least at the upper end) then you have a reason for doing so.
If you are using 'logarithmic' calibrators (Hötzi's expression) then you have a reason for doing so.

It is that reason -whatever it might be it isn't part of this discussion from my side- that determines whether or not you are aiming at using the geometric mean or the mean or the median or Harmonica Lewinsky's mean or something entirely else for the mid-level QC.

—
Pass or fail!
ElMaestro

Complete thread:

determining the QC medium haydonat 2012-10-18 00:26 [Bioanalytics]
- QC medium: short answer Helmut 2012-10-18 16:14
  - QC medium: short answer ElMaestro 2012-10-18 16:51
- QC medium: lengthy answer Helmut 2012-10-19 15:47
  - QC medium concentration in 2014 Debbie 2014-06-10 19:42
    - ~geometric mean of range Helmut 2014-06-17 14:30
      - ~geometric mean of range nobody 2014-06-17 14:49
        
        ~geometric mean of range Helmut 2014-06-17 15:11
        
        ~geometric mean of range nobody 2014-06-17 18:26
        
        ~geometric mean of range Helmut 2014-06-18 16:07
        
        compromiseElMaestro 2014-06-18 17:43
        
        compromise Ohlbe 2014-06-18 20:00
        
        compromise Helmut 2014-06-19 01:13
        
        compromise Ohlbe 2014-06-19 11:15
        
        compromise nobody 2014-06-19 14:10