Bioequivalence and Bioavailability Forum

Dear Helmut

For a regular 2x2x2 study performed with two dosing days groups, I've wrote the following code on SAS:

proc glm data=...;
classes sequence subject period formulation group
model logDATA= sequence period formulation subject(sequence) group formulation*group
etimate "test-ref" formulation -1+1;
test h=sequence e=subject(sequence);
lsmeans formulation / pdiff=control ("R) CL alpha=0.1;
run

On the output for the group effect, degrees of freedom were calculated as 0 and type I SS and type III SS were calculated as 0.00000000. For formulation*group effect, DF were computed as 1 and p_value as 0.7228 (for both type I and III SS).

I've also used phoenix with the following fixed effects: sequence + period + formulation + group + formulation*group
and subject(sequence) as random effect and I have obtained on both sequential tests and partial tests the same p_value of 0.7840 for group effect and 0.7228 for the interaction formulation*group.

Am I doing something wrong on SAS? Can you comment please! I'm very rookie with this software!
Best regards

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Edit: Category changed. [Helmut]