Bioequivalence and Bioavailability Forum

Qualitative analysis of the ANOVA residuals [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2014-02-19 15:22 (2440 d 04:58 ago) – Posting: # 12450
Views: 16,885

Hi Lucas,

» We've been asked to perform a qualitative analysis of the residuals of the ANOVA.

ANVISA?

» Now, I don't know what that analysis is supposed to acomplish, so I don't know what is supposed to be done.

IMHO, assessing the studentized residuals makes sense. See also Canada’s Guidance, Section 2.3.4.

1. From the model’s raw residuals calculate the standardized residuals (aka internally studentized residuals).
   
2. From them calculate the studentized residual (aka deleted studentized residual, extrenally studentized residual).

Both are directly accessible in SAS and R – and with a little bit of struggle – in Phoenix/WinNonlin. I would suggest to come up with a box-plot (optionally overlayed with jittered values) and ±3 as an optical reference. Looks like this:

—
Dif-tor heh smusma 🖖
Helmut Schütz


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Complete thread:

• Qualitative analysis of the ANOVA residuals Lucas 2014-02-19 14:27 [General Sta­tis­tics] 
  • Qualitative analysis of the ANOVA residualsHelmut 2014-02-19 15:22
    • Qualitative analysis of the ANOVA residuals Lucas 2014-02-19 15:58
      • Qualitative analysis of the ANOVA residuals Helmut 2014-02-19 16:25
        • Qualitative analysis of the ANOVA resid­uals Lucas 2014-02-19 17:20
        • Qualitative analysis of the ANOVA resid­u­als Lucas 2014-02-20 19:07
          • First hints for Phoenix Helmut 2014-02-20 20:11
          • Phoenix: resid­u­als Helmut 2014-02-21 19:25
            • Phoenix: resid­u­als BRN 2014-03-04 15:15
              • Phoenix: resid­u­als Helmut 2014-03-04 16:52
            • Phoenix: resid­u­als Rosy 2018-10-15 07:03
              • Software validation Helmut 2018-10-15 11:43
                • Software validation Rosy 2018-10-18 00:38
                  • Avoid raw residuals Helmut 2018-10-18 17:14
                    • Avoid raw residuals Rosy 2018-10-18 18:05
          • Phoenix → R Helmut 2014-02-23 02:20
            • Phoenix → R Lucas 2014-02-25 19:28
  • Qualitative analysis of the ANOVA residuals ElMaestro 2014-02-19 15:32
    • Qualitative analysis of the ANOVA residuals Helmut 2014-02-19 16:06
    • Qualitative analysis of the ANOVA residuals Lucas 2014-02-19 16:13
      • Qualitative analysis of the ANOVA resid­u­als ElMaestro 2014-02-19 20:40