PHX build 6.3.0.395 / 6.4.0.511 [Software]

posted by Helmut Homepage – Vienna, Austria, 2014-02-02 03:04 (3708 d 13:05 ago) – Posting: # 12310
Views: 25,870

Hi Yung-jin,

❝ […] Could you present the results (part of it will be good enough) from running PHX (or its beta)?


There are small differences to bear, since I started from the raw data and performed NCA first. This is a complete, balanced data set; therefore, the same results for subject(sequence) random or fixed are expected.

Table Partial SS

Dependent  Hypothesis       DF        SS        MS F_stat P_value
Ln(Cmax)   Sequence          1 0.0006903 0.0006903 0.02920 0.8672
Ln(Cmax)   Sequence*Subject 12 0.2836764 0.0236397 1.32782 0.3155
Ln(Cmax)   Formulation       1 0.0181691 0.0181691 1.02054 0.3323
Ln(Cmax)   Period            1 0.0362379 0.0362379 2.03545 0.1792
Ln(Cmax)   Error            12 0.2136406 0.0178034
Ln(AUCt)   Sequence          1 0.0151077 0.0151077 0.71554 0.4142
Ln(AUCt)   Sequence*Subject 12 0.2533637 0.0211136 0.63428 0.7791
Ln(AUCt)   Formulation       1 0.0108554 0.0108554 0.32611 0.5785
Ln(AUCt)   Period            1 0.0368259 0.0368259 1.10629 0.3136
Ln(AUCt)   Error            12 0.3994534 0.0332878
Ln(AUCinf) Sequence          1 0.0143291 0.0143291 0.76043 0.4003
Ln(AUCinf) Sequence*Subject 12 0.2261202 0.0188434 0.60445 0.8022
Ln(AUCinf) Formulation       1 0.0150303 0.0150303 0.48214 0.5007
Ln(AUCinf) Period            1 0.0346915 0.0346915 1.11282 0.3122
Ln(AUCinf) Error            12 0.3740929 0.0311744

This table is missing for the fixed effects model in the current release 6.3 (build 6.3.0.395) – therefore my work­around, but available in pre-release 1.4 (build 6.4.0.511).

Of course in the mixed model for AUCt and AUCinf:

Warning 11094: Negative final variance component. Consider omitting this VC structure.


Table Final Variance parameters (mixed)

Dependent  Parameter              Estimate
Ln(Cmax)   Var(Sequence*Subject)  0.0029182
Ln(Cmax)   Var(Residual)          0.0178034
Ln(Cmax)   Intersubject CV        0.0540594
Ln(Cmax)   Intrasubject CV        0.1340254
Ln(AUCt)   Var(Sequence*Subject) -0.0060871
Ln(AUCt)   Var(Residual)          0.0332878
Ln(AUCt)   Intrasubject CV        0.1839783
Ln(AUCinf) Var(Sequence*Subject) -0.0061655
Ln(AUCinf) Var(Residual)          0.0311744
Ln(AUCinf) Intrasubject CV        0.1779478


Table Final Variance parameters (fixed)

Dependent  Parameter              Estimate
Ln(Cmax)   Var(Residual)          0.0178034
Ln(AUCt)   Var(Residual)          0.0332878
Ln(AUCinf) Var(Residual)          0.0311744

Note the CVintra is not reported (why not?)…

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