Period effect [Off Topic]
Hi Kumar & Dan,
although it is interesting that you got only ~20–25% of period 1 in period 2, the behavior is consistent for both formulations and both PK metrics. The ratios are pretty close to 100%.
So it might be worthwhile to look for an explanation (were the suspensions in both periods prepared in exactly the same way and by the same personnel?). However, the BE assessment and – since this is a pilot study – the estimated PEs and CVs are not affected. The period effect means out in a cross-over study.
although it is interesting that you got only ~20–25% of period 1 in period 2, the behavior is consistent for both formulations and both PK metrics. The ratios are pretty close to 100%.
❝ This was a oral suspension.
So it might be worthwhile to look for an explanation (were the suspensions in both periods prepared in exactly the same way and by the same personnel?). However, the BE assessment and – since this is a pilot study – the estimated PEs and CVs are not affected. The period effect means out in a cross-over study.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
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- effectiveness of highly variable drugs Ken Peh 2013-12-20 14:38
- Period effect kumarnaidu 2014-01-28 07:54
- Period effect Dr_Dan 2014-01-28 10:36
- Period effect kumarnaidu 2014-01-28 11:51
- Period effectHelmut 2014-01-28 13:48
- Period effect kumarnaidu 2014-01-29 04:49
- Period effectHelmut 2014-01-28 13:48
- Period effect kumarnaidu 2014-01-28 11:51
- Period effect Dr_Dan 2014-01-28 10:36
- Period effect kumarnaidu 2014-01-28 07:54
- effectiveness of highly variable drugs Ken Peh 2013-12-20 14:38
- effectiveness of highly variable drugs Ohlbe 2013-12-18 10:07
- HVDs/HVDPs = safe drugs Helmut 2013-12-17 15:11