Bioequivalence and Bioavailability Forum • Winnonlin: exclude volunteers

Winnonlin: exclude volunteers [Software]

posted by mittyri – Russia, 2014-01-10 09:05 (3758 d 08:10 ago) – Posting: # 12153
Views: 15,364

Hi Helmut and All,

Sorry for out-of-date question, but I need to clarify one issue.

❝ Some ideas: Conventional 2×2 cross-over: Since Phoenix/WinNonlin only speaks REML, you have to exclude incomplete data. Unlike in SAS GLM (which ignores such cases) you have to filter for complete data in Phoenix first. Otherwise you are in mixed-effects model limbo.

In the study we have 2 volunteers who were discontinued the study after 1st period (both from same sequence)
Do I understand correct, that I shouldn't put the data from these subjects to WNL?
I tried both options (with and without them) and recieved unequal CIs

—
Kind regards,
Mittyri

Complete thread:

SAS vs Winnonlin jag009 2013-07-24 17:30 [Software]
- SAS vs Winnonlin Helmut 2013-07-24 17:55
  - SAS vs Winnonlin jag009 2013-07-24 22:56
    - SAS vs Winnonlin Helmut 2013-07-24 23:53
      - SAS vs Winnonlin jag009 2013-07-25 00:56
        
        EMA crippled approach d_labes 2013-07-25 09:13
        
        Hypothesis jag009 2013-07-25 15:38
        
        Two at a Time? Or All at Once? Helmut 2013-08-10 13:52
        
        Heteroscedasticity Helmut 2013-07-27 18:30
  - Update! jag009 2013-07-27 05:59
    - Rounding limbo? Helmut 2013-07-27 14:53
      - Rounding limbo? jag009 2013-07-27 22:02
  - Winnonlin: exclude volunteersmittyri 2014-01-10 08:05
    - Winnonlin: exclude incomplete data! Helmut 2014-01-10 13:41
- SAS vs Winnonlin ElMaestro 2013-07-24 18:06
  - SAS vs Winnonlin jag009 2013-07-24 22:59