effectiveness of highly variable drugs [Off Topic]
Dear Friends,
This is an off topic question.
We conducted BE studies on a highly variable drug, clopidogrel, a generic versus Plavix. The same subject who was dosed twice with the same product (irrespective of generic or comparator) showed drastic difference in AUC and Cmax. I was stunned when asked by a cardiologist what contributed to the high variability from the same product. Absorption, metabolism etc ?
Should highly variable drugs be used in clinical practice ??
Thank you for your kind sharing.
Regards,
Ken
This is an off topic question.
We conducted BE studies on a highly variable drug, clopidogrel, a generic versus Plavix. The same subject who was dosed twice with the same product (irrespective of generic or comparator) showed drastic difference in AUC and Cmax. I was stunned when asked by a cardiologist what contributed to the high variability from the same product. Absorption, metabolism etc ?
Should highly variable drugs be used in clinical practice ??
Thank you for your kind sharing.
Regards,
Ken
Complete thread:
- effectiveness of highly variable drugsKen Peh 2013-12-17 03:45 [Off Topic]
- HVDs/HVDPs = safe drugs Helmut 2013-12-17 15:11
- HVDs/HVDPs = safe drugs varun9461 2019-02-22 12:23
- effectiveness of highly variable drugs Dr_Dan 2013-12-18 09:34
- effectiveness of highly variable drugs Ohlbe 2013-12-18 10:07
- effectiveness of highly variable drugs Ken Peh 2013-12-20 14:38
- Period effect kumarnaidu 2014-01-28 07:54
- Period effect Dr_Dan 2014-01-28 10:36
- Period effect kumarnaidu 2014-01-28 11:51
- Period effect Helmut 2014-01-28 13:48
- Period effect kumarnaidu 2014-01-29 04:49
- Period effect Helmut 2014-01-28 13:48
- Period effect kumarnaidu 2014-01-28 11:51
- Period effect Dr_Dan 2014-01-28 10:36
- Period effect kumarnaidu 2014-01-28 07:54
- effectiveness of highly variable drugs Ken Peh 2013-12-20 14:38
- effectiveness of highly variable drugs Ohlbe 2013-12-18 10:07
- HVDs/HVDPs = safe drugs Helmut 2013-12-17 15:11