effectiveness of highly variable drugs [Off Topic]

posted by Ken Peh – Malaysia, 2013-12-17 02:45 (2428 d 02:25 ago) – Posting: # 12066
Views: 11,570

Dear Friends,

This is an off topic question.
We conducted BE studies on a highly variable drug, clopidogrel, a generic versus Plavix. The same subject who was dosed twice with the same product (irrespective of generic or comparator) showed drastic difference in AUC and Cmax. I was stunned when asked by a cardiologist what contributed to the high variability from the same product. Absorption, metabolism etc :confused:?

Should highly variable drugs be used in clinical practice ??

Thank you for your kind sharing.

Regards,
Ken

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