Bioequivalence and Bioavailability Forum

Nonlinear nightmare [General Sta­tis­tics]

posted by jag009  – NJ, 2013-11-25 18:43 (4223 d 11:06 ago) – Posting: # 11963
Views: 15,085

Hi Helmut!

Goodie. Have you goofed around with DDI before (drug interaction->inhibition)?

You can't run carbamazepine single dose BE due to autoinduction. We ran the BE program before and went with multiple-dose studies with no washout period like 8 yrs ago. I hope no one did...

I don't have Laszlo's paper so I don't know the details. i will ask him/them for one since both Ls are my former prof and postdoc. The Hungarian Dynmaic Duos

John

Complete thread:

• Simulation of data to predict Steady state cakhatri 2013-11-24 10:13 [General Sta­tis­tics] 
  • Nonparametric superposition Helmut 2013-11-24 14:30
    • Nonparametric superposition jag009 2013-11-24 23:13
      • Nonlinear nightmare Helmut 2013-11-25 02:56
        • Nonlinear nightmarejag009 2013-11-25 17:43
          • Nonlinear nightmare Helmut 2013-11-26 14:32
            • Nonlinear nightmare jag009 2013-11-26 16:00
              • OT: Vienna Helmut 2013-11-26 16:27
                • OT: Vienna jag009 2013-11-26 17:29
                  • OT: Vienna Helmut 2013-11-27 13:04
    • Conc at dosing interval jag009 2013-11-25 17:48
      • Conc at dosing interval Helmut 2013-11-26 15:01
        • Conc at dosing interval jag009 2013-11-26 17:31
          • Conc at dosing interval Helmut 2013-11-27 13:10
            • Conc at dosing interval jag009 2013-11-27 20:00
            • Passing SD and Failing MD luvblooms 2013-11-28 09:19
              • Passing SD and Failing MD Helmut 2013-11-29 17:29
                • Passing SD and Failing MD luvblooms 2013-11-29 18:57
                  • Cτ predictive of Cmin Helmut 2013-11-30 17:25