Nonparametric superposition [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2013-11-24 15:30 (3407 d 20:19 ago) – Posting: # 11952
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Hi Chirag,

❝ Is there any way of simulating the data to predict steady state from the pilot study data?

Two ways.
  1. PK modeling.
  2. Nonparametric superposition.
For both you need a reliable estimate of the slowest phase (elimination or absorption if ka < kel) and have to assume:#1 is tricky. Therefore, I would suggest #2.
For an example in WinNonlin 5.x see this post. Easier in Phoenix.


BTW, look at the steady state profiles and the inserted plot. Compared to single dose tmax slightly shifts towards earlier times. Sometimes it makes sense not to blindly use the single dose’s sampling time schedule, but to adjust it accordingly.

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