Log in
RegisterpAUCs [Study Performance]
posted by Helmut 
– Vienna, Austria, 2013-09-11 23:01 (4246 d 05:46 ago) – Posting: # 11482
Views: 10,225
Hi John,
Why not? As you know we work on the same drugs (pAUCs standard). Never had a problem. Of course I describe the procedure in the protocol and even give an example plot similar to that one …
… showing how pAUCs, t75%, and HVD are calculated. Samples denoted with an orange circle were not taken at scheduled time points – they were either interpolated (at t=0 and t=4) or extrapolated (t=24).
I thought that you don’t have the 3.5 sample (delayed till 4:11)? But you have the one at 4:02. Interpolate between this one and the one before. If you feel that you are reaching too far “to the left”, drop the AUCs and keep the Cmax.
Who told you that?
Did you never have small time deviations close to the truncation time point and asked Phoenix/WinNonlin for partial AUCs? If yes, I’m surprised. If no, guess what was going on behind the veil (or look it up in the User’s Guide).
❝ ❝ BTW, if you ask Phoenix/WinNonlin for partial AUCs (and sampling wasn’t performed exactly at the cut-off time point) an interpolation between two adjacent time points (before/after) is used; linear if C2 ≥ C1 and log/linear if C2 < C1. Makes sense, IMHO.
❝
❝ I don't think you can make interpolation to obtain the concentration at the desire time right
Why not? As you know we work on the same drugs (pAUCs standard). Never had a problem. Of course I describe the procedure in the protocol and even give an example plot similar to that one …
![[image]](img/uploaded/image76.png)
… showing how pAUCs, t75%, and HVD are calculated. Samples denoted with an orange circle were not taken at scheduled time points – they were either interpolated (at t=0 and t=4) or extrapolated (t=24).
❝ (example: interpolate 4 hr concentration from 3.5 hr and 4.25 hr concentration)?
I thought that you don’t have the 3.5 sample (delayed till 4:11)? But you have the one at 4:02. Interpolate between this one and the one before. If you feel that you are reaching too far “to the left”, drop the AUCs and keep the Cmax.
❝ I thought you have to use the time point as is?
Who told you that?
Did you never have small time deviations close to the truncation time point and asked Phoenix/WinNonlin for partial AUCs? If yes, I’m surprised. If no, guess what was going on behind the veil (or look it up in the User’s Guide).
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Boneheads! jag009 2013-09-09 21:12 [Study Performance]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- WTF ? Ohlbe 2013-09-09 21:26
- Snafued! Helmut 2013-09-09 21:55
- Snafued! WTF! &%$@! jag009 2013-09-10 16:11
- pAUCsHelmut 2013-09-11 21:01
- pAUCs - the SEQUEL jag009 2013-09-12 20:48
- A Nightmare on Elm Street Helmut 2013-09-13 00:55
- A Nightmare on Elm Street jag009 2013-09-13 15:26
- A Nightmare on Elm Street Helmut 2013-09-13 16:00
- A Nightmare on Elm Street jag009 2013-09-13 19:57
- A Nightmare on Elm Street Helmut 2013-09-13 16:00
- A Nightmare on Elm Street jag009 2013-09-13 15:26
- A Nightmare on Elm Street Helmut 2013-09-13 00:55
- pAUCs - the SEQUEL jag009 2013-09-12 20:48
- pAUCsHelmut 2013-09-11 21:01
- Snafued! WTF! &%$@! jag009 2013-09-10 16:11
- WTF ? jag009 2013-09-10 16:13
- Snafued! Helmut 2013-09-09 21:55
- WTF ? Ohlbe 2013-09-09 21:26
Ing. Helmut Schütz