Bioequivalence and Bioavailability Forum

Partial AUC? [NCA / SHAM]

posted by Helmut  – Vienna, Austria, 2013-08-28 19:42 (4315 d 07:28 ago) – Posting: # 11372
Views: 10,450

Hi Dan,

❝ What do you think about this parameter?:

❝ partialAUC_{(0-Tmax)+(Tmax-T75%Cmax)}

Not sure which time point(s) you mean for truncation. See the following example:
 0.5167 BQL
 1      1.144
 1.5    2.399
 2      3.226
 2.5    3.236
 3      2.943
 3.5    2.776
 4      3.393
 4.5    4.736
 5      3.934
 6      3.387
 9      1.643
12.0333 0.717
16.0167 0.231
t_max 4.5, C_max 4.736, 75%C_max 3.552. In Phoenix/WinNonlin-style that would mean linear inter­po­la­tion in the increasing sections (—) and loglinear in the decreasing sections (—).* Therefore, the first intersection is at 4.059 and the second one at 5.682; t_75% 1.623.



In PHX/WNL you get the area above 75%C_max (0.774) and below (28.101) but I don’t think that this is what you had in mind.

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• Irrespective of which trapezoidal rule is set. The same is true for partial AUCs.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Russian Guidance – PK Data assay Karthikeyan 2013-08-27 13:54 [NCA / SHAM] 
  • Plateau-time etc. Helmut 2013-08-27 14:44
  • Russian Guidance – PK Data assay Dr_Dan 2013-08-27 15:39
    • Russian Guidance – PK Data assay Helmut 2013-08-27 16:31
      • t75% Dr_Dan 2013-08-27 16:56
        • t75% Helmut 2013-08-27 17:37
          • t75% mittyri 2013-08-28 09:51
            • t75% (reporting only?) Helmut 2013-08-28 14:32
    • Partial AUC?Helmut 2013-08-28 17:42
      • Partial AUC? Dr_Dan 2013-08-28 21:08
        • Partial AUC? Karthikeyan 2013-08-29 14:04