Bioequivalence and Bioavailability Forum • t75%

t75% [NCA / SHAM]

posted by Helmut – Vienna, Austria, 2013-08-27 19:37 (4315 d 06:49 ago) – Posting: # 11361
Views: 10,383

Hi Dan,

❝ ❝ the plateau time t_75% is a rather old PK metric

❝ maybe I am too young, I never heard of it... ;-)

Die Gnade der späten Geburt.

❝ However, what would be the advantage of this parameter?

Useful for multiple peaks (see this example) and “flat profiles”. If you compare C_max that might be apples-and-oranges-statistics. Actually Steinijans & Co. introduced this metric for prolonged release theophylline (see also the book by Hauschke, Steinijans, and Pigeot). I those dark ages there was even a saying:

“Volker Steinijans and his wife Theophylline”. :-D

❝ Would it be possible to be bioequivalent with regard to AUC and C_max but failing with regard to t_75%?

Yes, it is, The Lászlós (who else?) have shown that. Will excavate the reference.

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Complete thread:

Russian Guidance – PK Data assay Karthikeyan 2013-08-27 13:54 [NCA / SHAM]
- Plateau-time etc. Helmut 2013-08-27 14:44
- Russian Guidance – PK Data assay Dr_Dan 2013-08-27 15:39
  - Russian Guidance – PK Data assay Helmut 2013-08-27 16:31
    - t75% Dr_Dan 2013-08-27 16:56
      - t75%Helmut 2013-08-27 17:37
        
        t75% mittyri 2013-08-28 09:51
        
        t75% (reporting only?) Helmut 2013-08-28 14:32
  - Partial AUC? Helmut 2013-08-28 17:42
    - Partial AUC? Dr_Dan 2013-08-28 21:08
      - Partial AUC? Karthikeyan 2013-08-29 14:04