Three-way crossover (WinNonlin) [Design Issues]

posted by Nirali  – India, 2007-09-25 10:05 (6083 d 02:19 ago) – Posting: # 1127
Views: 30,591

Dear Helmut,

Actully, I was under impression that WinNonlin is using the hypo:

As I understood from your reply--
(A) suppose we have two REFERENCES and single TEST [R1, R2, T]for threeway comparison: if we select R1 as REFERENCE, WNL will calculate BE with hypo:
(1) R1=T and (2) R1=R2.

same way,
(B) for two TEST and single REFERENCE [T1, T2, R]: if we select R as standard, hypo will be: (1) R=T1 and (2)R=T2

pls do correnct me if i am wrong to understand.

Thanks & Regards,

Complete thread:

UA Flag
 Admin contact
23,034 posts in 4,835 threads, 1,647 registered users;
33 visitors (0 registered, 33 guests [including 5 identified bots]).
Forum time: 12:25 CEST (Europe/Vienna)

Give me a fruitful error any time, full of seeds, bursting with its own corrections.
You can keep your sterile truth for yourself.    Vilfredo Pareto

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz