Three-way crossover (WinNonlin) [Design Issues]

posted by Nirali  – India, 2007-09-25 08:05  – Posting: # 1127
Views: 15,123

Dear Helmut,

Actully, I was under impression that WinNonlin is using the hypo:
"MEAN(Test1)=MEAN(Test2)=MEAN(Ref)".


As I understood from your reply--
(A) suppose we have two REFERENCES and single TEST [R1, R2, T]for threeway comparison: if we select R1 as REFERENCE, WNL will calculate BE with hypo:
(1) R1=T and (2) R1=R2.

same way,
(B) for two TEST and single REFERENCE [T1, T2, R]: if we select R as standard, hypo will be: (1) R=T1 and (2)R=T2

pls do correnct me if i am wrong to understand.

Thanks & Regards,
Nirali

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