Bioequivalence and Bioavailability Forum • Three-way crossover (WinNonlin)

Three-way crossover (WinNonlin) [Design Issues]

posted by Nirali – India, 2007-09-25 10:05 (6051 d 08:02 ago) – Posting: # 1127
Views: 30,295

Dear Helmut,

Actully, I was under impression that WinNonlin is using the hypo:
"MEAN(Test1)=MEAN(Test2)=MEAN(Ref)".

As I understood from your reply--
(A) suppose we have two REFERENCES and single TEST [R1, R2, T]for threeway comparison: if we select R1 as REFERENCE, WNL will calculate BE with hypo:
(1) R1=T and (2) R1=R2.

same way,
(B) for two TEST and single REFERENCE [T1, T2, R]: if we select R as standard, hypo will be: (1) R=T1 and (2)R=T2

pls do correnct me if i am wrong to understand.

Thanks & Regards,
Nirali

Complete thread:

Three-way crossover BABE Studies acfalcao 2007-09-16 22:34
- Three-way crossover example data set Helmut 2007-09-17 20:47
  - Three-way crossover example data set acfalcao 2007-09-17 23:02
    - Three-way crossover example data set Helmut 2007-09-18 12:47
      - Three-way crossover (WinNonlin) Nirali 2007-09-21 06:49
        
        Three-way crossover (WinNonlin) Helmut 2007-09-21 13:04
        
        Three-way crossover (WinNonlin)Nirali 2007-09-25 08:05
        
        Three-way crossover (WinNonlin) Helmut 2007-09-25 13:15
      - Three-way crossover example data set Irene_I 2018-06-07 11:09
        
        Three-way crossover example data set Helmut 2018-06-07 13:04
        
        Three-way crossover example data set Irene_I 2018-06-08 11:09
        Three-way crossover example data set Irene_I 2018-06-12 09:21
        
        Leave-One-Out (IBD) Helmut 2018-06-12 12:42
        
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