Three-way crossover (WinNonlin) [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2007-09-21 15:04 (6049 d 09:53 ago) – Posting: # 1109
Views: 30,291

Dear Nirali,

❝ Which hypothesis Winnonlin will use while running BE for 2 test (T1 & T2) vs a reference (R)?

❝ Would it be "MEAN(T1)=MEAN(T2)=MEAN(R)"?

❝ In threeway crossover study, does we try to compare Equivalence of all three product together?


Comparisons are based on paired differences; IMHO a simultaneous test of T1=T2=R is not possible.
WinNonlin always uses one reference in a run, i.e., T1=R (one test), and T2=R (the second test).
If you are interested in T1=T2 you have to start a second run (defining T2 as the reference), and will obtain two tests (T1=T2 and R=T2) within.

BTW, why are you interested in T1=T2?

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,982 posts in 4,822 threads, 1,648 registered users;
34 visitors (0 registered, 34 guests [including 8 identified bots]).
Forum time: 00:58 CEST (Europe/Vienna)

To call the statistician after the experiment is done
may be no more than asking him to perform a postmortem examination:
he may be able to say what the experiment died of.    R.A. Fisher

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5