Three-way crossover (WinNonlin) [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2007-09-21 15:04 (5663 d 16:17 ago) – Posting: # 1109
Views: 27,742

Dear Nirali,

❝ Which hypothesis Winnonlin will use while running BE for 2 test (T1 & T2) vs a reference (R)?

❝ Would it be "MEAN(T1)=MEAN(T2)=MEAN(R)"?

❝ In threeway crossover study, does we try to compare Equivalence of all three product together?

Comparisons are based on paired differences; IMHO a simultaneous test of T1=T2=R is not possible.
WinNonlin always uses one reference in a run, i.e., T1=R (one test), and T2=R (the second test).
If you are interested in T1=T2 you have to start a second run (defining T2 as the reference), and will obtain two tests (T1=T2 and R=T2) within.

BTW, why are you interested in T1=T2?

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
 Admin contact
22,550 posts in 4,724 threads, 1,606 registered users;
15 visitors (0 registered, 15 guests [including 8 identified bots]).
Forum time: 06:22 CET (Europe/Vienna)

If there is an exception to any rule,
and if it can be proved by observation,
that rule is wrong.    Richard Feynman

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz