Three-way crossover (WinNonlin) [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2007-09-21 13:04  – Posting: # 1109
Views: 16,773

Dear Nirali,

» Which hypothesis Winnonlin will use while running BE for 2 test (T1 & T2) vs a reference (R)?
» Would it be "MEAN(T1)=MEAN(T2)=MEAN(R)"?
» In threeway crossover study, does we try to compare Equivalence of all three product together?

Comparisons are based on paired differences; IMHO a simultaneous test of T1=T2=R is not possible.
WinNonlin always uses one reference in a run, i.e., T1=R (one test), and T2=R (the second test).
If you are interested in T1=T2 you have to start a second run (defining T2 as the reference), and will obtain two tests (T1=T2 and R=T2) within.

BTW, why are you interested in T1=T2?

Cheers,
Helmut Schütz
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