Bioequivalence and Bioavailability Forum • Three-way crossover (WinNonlin)

Three-way crossover (WinNonlin) [Design Issues]

posted by Helmut – Vienna, Austria, 2007-09-21 15:04 (6446 d 16:21 ago) – Posting: # 1109
Views: 40,503

Dear Nirali,

❝ Which hypothesis Winnonlin will use while running BE for 2 test (T1 & T2) vs a reference (R)?

❝ Would it be "MEAN(T1)=MEAN(T2)=MEAN(R)"?

❝ In threeway crossover study, does we try to compare Equivalence of all three product together?

Comparisons are based on paired differences; IMHO a simultaneous test of T₁=T₂=R is not possible.
WinNonlin always uses one reference in a run, i.e., T₁=R (one test), and T₂=R (the second test).
If you are interested in T₁=T₂ you have to start a second run (defining T₂ as the reference), and will obtain two tests (T₁=T₂ and R=T₂) within.

BTW, why are you interested in T₁=T₂?

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Complete thread:

Three-way crossover BABE Studies acfalcao 2007-09-16 22:34 [Design Issues]
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