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RegisterSAS vs Winnonlin [Software]
Hi Helmut,
It is a 3-way 2 test vs reference study (tada! You guessed it! We have common/pool variance!)
Well the data I have is not complete, one subject is missing period 3 (withdrew) but I elected to keep his periods 1 and 2 data since period 2 was the reference arm. I used GLM in SAS and then for my own amusement I ran the data in Phoenix...
John
❝ Some ideas:
❝ • Conventional 2×2 cross-over: Since Phoenix/WinNonlin only speaks REML, you have to exclude incomplete data. Unlike in SAS GLM (which ignores such cases) you have to filter for complete data in Phoenix first. Otherwise you are in mixed-effects model limbo. For the EMA you have to treat all effects fixed. In Phoenix that means: Delete subject(sequence) in the variance structure / random1 tab and add it to the fixed effects.
❝ • Higher-order Xover (say two references). Same as above, but for the EMA you have to exclude the “uninteresting” treatment, while for the FDA I guess (!) you keep all in the model and report only the relevant pair. That’s independent from the software you use.
It is a 3-way 2 test vs reference study (tada! You guessed it! We have common/pool variance!)
Well the data I have is not complete, one subject is missing period 3 (withdrew) but I elected to keep his periods 1 and 2 data since period 2 was the reference arm. I used GLM in SAS and then for my own amusement I ran the data in Phoenix...
John
Complete thread:
- SAS vs Winnonlin jag009 2013-07-24 17:30 [Software]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- SAS vs Winnonlin Helmut 2013-07-24 17:55
- SAS vs Winnonlinjag009 2013-07-24 22:56
- SAS vs Winnonlin Helmut 2013-07-24 23:53
- SAS vs Winnonlin jag009 2013-07-25 00:56
- EMA crippled approach d_labes 2013-07-25 09:13
- Hypothesis jag009 2013-07-25 15:38
- Two at a Time? Or All at Once? Helmut 2013-08-10 13:52
- Heteroscedasticity Helmut 2013-07-27 18:30
- Hypothesis jag009 2013-07-25 15:38
- EMA crippled approach d_labes 2013-07-25 09:13
- SAS vs Winnonlin jag009 2013-07-25 00:56
- SAS vs Winnonlin Helmut 2013-07-24 23:53
- Update! jag009 2013-07-27 05:59
- Rounding limbo? Helmut 2013-07-27 14:53
- Rounding limbo? jag009 2013-07-27 22:02
- Rounding limbo? Helmut 2013-07-27 14:53
- Winnonlin: exclude volunteers mittyri 2014-01-10 08:05
- Winnonlin: exclude incomplete data! Helmut 2014-01-10 13:41
- SAS vs Winnonlinjag009 2013-07-24 22:56
- SAS vs Winnonlin ElMaestro 2013-07-24 18:06
- SAS vs Winnonlin jag009 2013-07-24 22:59
- SAS vs Winnonlin Helmut 2013-07-24 17:55
Ing. Helmut Schütz