SAS vs Winnonlin [Software]
Hi John,
EMA:
Some ideas:
❝ Since both SAS and WinNonlin results are submittable for FDA (EMA?), …
EMA:
❝ … what if my results are borderline passing the 90% CI with SAS and borderline failing the 90% CI with WinNonlin?
❝ Just an example: SAS gives 79.85% - 99.93%, while WinNonlin gives 80.15% - 100.52%.
Some ideas:
- Conventional 2×2 cross-over: Since Phoenix/WinNonlin only speaks REML, you have to exclude incomplete data. Unlike in SAS GLM (which ignores such cases) you have to filter for complete data in Phoenix first. Otherwise you are in mixed-effects model limbo. For the EMA you have to treat all effects fixed. In Phoenix that means: Delete
subject(sequence)
in the variance structure / random1 tab and add it to the fixed effects.
- Higher-order Xover (say two references). Same as above, but for the EMA you have to exclude the “uninteresting” treatment, while for the FDA I guess (!) you keep all in the model and report only the relevant pair. That’s independent from the software you use.
- Replicate designs / scaling: Cave – FDA and EMA have different models.
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- SAS vs Winnonlin jag009 2013-07-24 17:30 [Software]
- SAS vs WinnonlinHelmut 2013-07-24 17:55
- SAS vs Winnonlin jag009 2013-07-24 22:56
- SAS vs Winnonlin Helmut 2013-07-24 23:53
- SAS vs Winnonlin jag009 2013-07-25 00:56
- EMA crippled approach d_labes 2013-07-25 09:13
- Hypothesis jag009 2013-07-25 15:38
- Two at a Time? Or All at Once? Helmut 2013-08-10 13:52
- Heteroscedasticity Helmut 2013-07-27 18:30
- Hypothesis jag009 2013-07-25 15:38
- EMA crippled approach d_labes 2013-07-25 09:13
- SAS vs Winnonlin jag009 2013-07-25 00:56
- SAS vs Winnonlin Helmut 2013-07-24 23:53
- Update! jag009 2013-07-27 05:59
- Rounding limbo? Helmut 2013-07-27 14:53
- Rounding limbo? jag009 2013-07-27 22:02
- Rounding limbo? Helmut 2013-07-27 14:53
- Winnonlin: exclude volunteers mittyri 2014-01-10 08:05
- Winnonlin: exclude incomplete data! Helmut 2014-01-10 13:41
- SAS vs Winnonlin jag009 2013-07-24 22:56
- SAS vs Winnonlin ElMaestro 2013-07-24 18:06
- SAS vs Winnonlin jag009 2013-07-24 22:59
- SAS vs WinnonlinHelmut 2013-07-24 17:55