Bioequivalence and Bioavailability Forum • Brent

Brent [PK / PD]

posted by ElMaestro – Denmark, 2013-07-18 11:07 (4302 d 09:20 ago) – Posting: # 11015
Views: 22,278

Hi d_labes,

❝ Can you enlighten me what the reason was to choose method="Brent"?

For the case of a one-dimensional optimisation problem, the Nelder-Mead is as unreliable as a used-car sales man. In such cases Brent is a good choice. If we want to do two-dimensional (or more) optimisation then I'd probably go with the default Nelder-Mead.

Along these lines: Yung-jin, for a two-dimensional problem as discussed above the Nelder-Mead etc. may perform much more efficiently than a grid search.

Re. the TTT rule: I have no experience with it in practice. It sounds like something that for all practical pruposes should be good enough.

—
Pass or fail!
ElMaestro

Complete thread:

1 compartment model with lag time jag009 2013-07-17 15:58 [PK / PD]
- solve for k01? Helmut 2013-07-17 16:08
  - solve for k01? jag009 2013-07-17 16:19
    - solve for k01? ElMaestro 2013-07-17 17:09
    - no closed form Helmut 2013-07-17 23:01
- 1 compartment model with lag time yjlee168 2013-07-17 20:57
- Package-free solution ElMaestro 2013-07-17 21:53
  - Package-free solution yjlee168 2013-07-17 22:11
    - Package-free solution ElMaestro 2013-07-17 22:27
      - Package-free solution yjlee168 2013-07-17 22:42
  - Package-free solution ElMaestro 2013-07-17 23:21
    - A new R-King was born d_labes 2013-07-18 08:45
      - BrentElMaestro 2013-07-18 09:07
      - A new R-King was born yjlee168 2013-07-18 10:21
        
        OT: TTT in bear Helmut 2013-07-18 20:28
        
        OT: TTT in bear yjlee168 2013-07-18 22:17
        
        OT: TTT subtleties d_labes 2013-07-19 09:47
        
        OT: TTT subtleties yjlee168 2013-07-20 19:44
        
        OT: beyond TTT? Helmut 2013-07-21 00:08
        
        OT: beyond TTT? yjlee168 2013-07-22 13:45
        
        OT: keep TTT! Helmut 2013-07-22 14:21
        
        OT: keep TTT! yjlee168 2013-07-22 23:42
        
        OT: EOD (here) Helmut 2013-07-23 01:06
    - Package-free solution yjlee168 2013-07-18 10:27
      - Thank you guys! jag009 2013-07-18 16:37
        
        Thank you guys! ElMaestro 2013-07-18 18:57
        
        Thank you guys! jag009 2013-07-19 20:40