A new R-King was born [PK / PD]

posted by d_labes  – Berlin, Germany, 2013-07-18 10:45 (4354 d 14:46 ago) – Posting: # 11014
Views: 22,660

Mei liaba Kokoschinsky!
(bajuvarian)

:thumb up: Respect!

Can you enlighten me what the reason was to choose method="Brent"?

The range 0.001-100 is surely nearly exhaustive for k01 (elimination constant), but if elimination half life is >693.1472 hours ... :-D

What about the simple solution: "Log-linear regression of points after two times tmax (known as TTT rule), negative slope =k01"?
Of course restricted to one-compartiment model.

@John:
A general criticism: I don't understand the problem. If we have concentration time points and fit a one-compartiment model we get all the parameters necessary for that model, including k01. I can't imagine situations where we have V, k10, t, tlag only but no k01.

Regards,

Detlew

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