Bioequivalence and Bioavailability Forum • no closed form

no closed form [PK / PD]

posted by Helmut – Vienna, Austria, 2013-07-18 01:01 (4302 d 10:44 ago) – Posting: # 11010
Views: 22,145

Hi John,

after unsuccessfully fiddling with paper, pencil, and a little brain I decided to fire up my symbolic algebra system Maxima.*

Seems that this equation cannot be solved in closed form. So you have to go with one of the numerical algos suggested by Yung-jin and ElMaestro.

If you want to give it a try yourself: Get Maxima and install wxMaxima as GUI. I don’t recommend the native GUI xMaxima.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Complete thread:

1 compartment model with lag time jag009 2013-07-17 15:58 [PK / PD]
- solve for k01? Helmut 2013-07-17 16:08
  - solve for k01? jag009 2013-07-17 16:19
    - solve for k01? ElMaestro 2013-07-17 17:09
    - no closed formHelmut 2013-07-17 23:01
- 1 compartment model with lag time yjlee168 2013-07-17 20:57
- Package-free solution ElMaestro 2013-07-17 21:53
  - Package-free solution yjlee168 2013-07-17 22:11
    - Package-free solution ElMaestro 2013-07-17 22:27
      - Package-free solution yjlee168 2013-07-17 22:42
  - Package-free solution ElMaestro 2013-07-17 23:21
    - A new R-King was born d_labes 2013-07-18 08:45
      - Brent ElMaestro 2013-07-18 09:07
      - A new R-King was born yjlee168 2013-07-18 10:21
        
        OT: TTT in bear Helmut 2013-07-18 20:28
        
        OT: TTT in bear yjlee168 2013-07-18 22:17
        
        OT: TTT subtleties d_labes 2013-07-19 09:47
        
        OT: TTT subtleties yjlee168 2013-07-20 19:44
        
        OT: beyond TTT? Helmut 2013-07-21 00:08
        
        OT: beyond TTT? yjlee168 2013-07-22 13:45
        
        OT: keep TTT! Helmut 2013-07-22 14:21
        
        OT: keep TTT! yjlee168 2013-07-22 23:42
        
        OT: EOD (here) Helmut 2013-07-23 01:06
    - Package-free solution yjlee168 2013-07-18 10:27
      - Thank you guys! jag009 2013-07-18 16:37
        
        Thank you guys! ElMaestro 2013-07-18 18:57
        
        Thank you guys! jag009 2013-07-19 20:40