Three-way crossover example data set [Design Issues]

posted by Helmut Homepage – Vienna, Austria, 2007-09-18 12:47  – Posting: # 1092
Views: 15,403

Dear Amilcar!

» Thank you very much for your help. The correct codification of "sequences/periods" is the key for this problem. Unfortunately the link to download the SAS files was not working. I hope it can be solve in a near future.

Please try it again (it worked yesterday, and today as well): CRC’s website
Having downloaded the file, unzip it keeping folder's structure; in folder [chapter4] you will find: (the SAS code)
Example45.SSC (the S+ code)
exam45.dat (the raw data for S+)

As I get from the SAS-code a mixed model (degrees of freedom according to Kenward) was used, whereas WinNonlin uses Satterthwaite's method.
The S+ code does not calculate BE, but is used for the example’s figures only.

Edit: Wrong link corrected in both posts. [Helmut]

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes

Complete thread:

 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,818 posts in 4,201 threads, 1,361 registered users;
online 5 (0 registered, 5 guests [including 4 identified bots]).
Forum time (Europe/Vienna): 18:31 CEST

If I find 10,000 ways something won’t work, I haven’t failed.
I am not discouraged, because every wrong attempt discarded
is another step forward.    Thomas Alva Edison

BEBAC Ing. Helmut Schütz