Bioequivalence and Bioavailability Forum • Three-way crossover example data set

Three-way crossover example data set [Design Issues]

posted by Helmut – Vienna, Austria, 2007-09-18 10:47 (4820 d 14:40 ago) – Posting: # 1092
Views: 20,353

Dear Amilcar!

» Thank you very much for your help. The correct codification of "sequences/periods" is the key for this problem. Unfortunately the link to download the SAS files was not working. I hope it can be solve in a near future.

Please try it again (it worked yesterday, and today as well): CRC’s website
Having downloaded the file C5300.zip, unzip it keeping folder's structure; in folder [chapter4] you will find:
Example4.5.sas (the SAS code)
Example45.SSC (the S+ code)
exam45.dat (the raw data for S+)

As I get from the SAS-code a mixed model (degrees of freedom according to Kenward) was used, whereas WinNonlin uses Satterthwaite's method.
The S+ code does not calculate BE, but is used for the example’s figures only.

Edit: Wrong link corrected in both posts. [Helmut]

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Complete thread:

Three-way crossover BABE Studies acfalcao 2007-09-16 22:34 [Design Issues]
- Three-way crossover example data set Helmut 2007-09-17 20:47
  - Three-way crossover example data set acfalcao 2007-09-17 23:02
    - Three-way crossover example data setHelmut 2007-09-18 12:47
      - Three-way crossover (WinNonlin) Nirali 2007-09-21 06:49
        
        Three-way crossover (WinNonlin) Helmut 2007-09-21 13:04
        
        Three-way crossover (WinNonlin) Nirali 2007-09-25 08:05
        
        Three-way crossover (WinNonlin) Helmut 2007-09-25 13:15
      - Three-way crossover example data set Irene_I 2018-06-07 11:09
        
        Three-way crossover example data set Helmut 2018-06-07 13:04
        
        Three-way crossover example data set Irene_I 2018-06-08 11:09
        Three-way crossover example data set Irene_I 2018-06-12 09:21
        
        Leave-One-Out (IBD) Helmut 2018-06-12 12:42
        
        Leave-One-Out (IBD) Irene_I 2018-06-13 05:02
        
        Impact of pooled variance (bias, CI) Helmut 2018-06-13 15:02
        
        carry (over?) d_labes 2018-06-13 15:31
  - Pseudo-periods ElAlumno 2019-03-14 23:40
    - Pseudo-periods Helmut 2019-03-15 00:47
      - Two‐at‐a‐Time analysis in R ElAlumno 2019-03-22 21:59
        
        fixed & mixed (dammit!) and a request to SASians Helmut 2019-03-23 01:03
        
        Pooled vs IBD T-R in SAS from non-SASian mittyri 2019-03-23 23:13
        
        Pooled vs IBD T-R in SAS from non-SASian Helmut 2019-03-23 23:36
        
        mixed in R mittyri 2019-03-23 23:50
        
        mixed in R (EMA B ≠ FDA) Helmut 2019-03-24 01:23