Bioequivalence and Bioavailability Forum

Different algos! [NCA / SHAM]

posted by Helmut  – Vienna, Austria, 2013-05-31 00:38 (4402 d 04:34 ago) – Posting: # 10690
Views: 20,109

Hi Ken!

❝ ❝ linlog: C12*=exp(log(33.17)+|(12-8)/(16-8)|log(7.86/33.17))=16.15

❝ How did you get the readings of 16.15? I tried to follow your equation but I could not get the answer.

R
round(exp(log(33.17)+abs((12-8)/(16-8))*log(7.86/33.17)), 2)
[1] 16.15
SAS
x=round(exp(log(33.17)+abs((12-8)/(16-8))*log(7.86/33.17)), 2);
16.15
Excel / OO Calc / Gnumeric
=ROUND(EXP(LN(33.17)+ABS((12-8)/(16-8))*LN(7.86/33.17)), 2)
16.15

❝ linear/lin imp and linear/log imp have the same data set. Why the output is different ?

Since I’m using different algorithms. Once more: Forget linear interpolation in the descending part of the profile.



Have you ever asked yourself why the arithmetic and geometric means of the same data are different?
Compare (7.86+33.17)*0.5
with     (7.86*33.17)^0.5
Are these values vaguely reminiscent of something you have seen before?

❝ ❝ linlog: pAUC8-16=(16-8)(7.86-33.17)/log(7.86/33.17)=140.6

❝ Similarly, I could not get the answer of 140.61.

round((16-8)*(7.86-33.17)/log(7.86/33.17), 1)
[1] 140.6
=ROUND((16-8)*(7.86-33.17)/LN(7.86/33.17), 1)
140.6

❝ How did you calculate ?

See above. And you?

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• handling of missing data gracehung 2013-05-20 07:35 [NCA / SHAM] 
  • Lin-up/log-down trapezoidal avoids most trouble Helmut 2013-05-20 14:22
    • Lin-up/log-down trapezoidal avoids most trouble yjlee168 2013-05-22 08:25
      • Multiple peaks: fallback to linear trapezoidal Helmut 2013-05-22 20:25
        • Multiple peaks: fallback to linear trapezoidal yjlee168 2013-05-22 21:57
          • No interpolation Helmut 2013-05-22 23:25
            • No interpolation yjlee168 2013-05-23 11:43
              • Spaghetti & other pasta Helmut 2013-05-23 15:15
                • Spaghetti & other pasta yjlee168 2013-05-23 20:47
                  • Spaghetti & other pasta Helmut 2013-05-23 21:29
                    • Spaghetti & other pasta yjlee168 2013-05-23 22:46
                      • Spaghetti & other pasta Helmut 2013-05-24 01:24
                        • Spaghetti & other pasta yjlee168 2013-05-24 09:17
            • No interpolation Ken Peh 2013-05-30 19:55
              • Different algos!Helmut 2013-05-30 22:38
                • Different algos! Ken Peh 2013-06-03 17:52
                  • Calculate what? Helmut 2013-06-03 18:11
      • Lin-up/log-down trapezoidal example Helmut 2013-05-25 15:09
        • Lin-up/log-down trapezoidal example yjlee168 2013-05-25 19:45
  • handling of missing data Ohlbe 2013-05-20 21:45
    • Sorry Helmut 2013-05-21 13:53
      • Sorry gracehung 2013-05-23 01:06
        • Uncertain time point Helmut 2013-05-23 01:35