Bioequivalence and Bioavailability Forum

No interpolation [NCA / SHAM]

posted by Ken Peh – Malaysia, 2013-05-30 21:55 (4344 d 22:13 ago) – Posting: # 10688
Views: 19,182

Dear Helmut,

❝ Interpolated values for imputation:

❝ linear: C12*=33.17+|(12-8)/(16-8)|(7.86-33.17)=20.52

ok.

❝ linlog: C12*=exp(log(33.17)+|(12-8)/(16-8)|log(7.86/33.17))=16.15

How did you get the readings of 16.15? I tried to follow your equation but I could not get the answer.

❝ Calculation based on imputed values:

❝ linear/lin imp.: pAUC8-16=0.5(12- 8)(33.17+20.52)+

❝                           0.5(16-12)(20.52+ 7.86)=164.1

❝ linear/log imp.: pAUC8-16=0.5(12- 8)(33.17+20.52)+

❝                           0.5(16-12)(20.52+ 7.86)=146.7

linear/lin imp and linear/log imp have the same data set. Why the output is different ?

❝ linlog/log imp.: pAUC8-16=(12- 8)(16.15-33.17)/log(16.15/33.17)+

❝                           (16-12)( 7.86-16.15)/log( 7.86/16.15)=140.6

❝

❝ Direct calculation without imputation:

❝ linear: pAUC8-16=0.5(16-8)(33.17+7.86)=164.1

ok.

❝ linlog: pAUC8-16=(16-8)(7.86-33.17)/log(7.86/33.17)=140.6

Similarly, I could not get the answer of 140.61. How did you calculate ?

Please kindly elaborate.

Thank you.

Ken

Complete thread:

• handling of missing data gracehung 2013-05-20 07:35 [NCA / SHAM] 
  • Lin-up/log-down trapezoidal avoids most trouble Helmut 2013-05-20 14:22
    • Lin-up/log-down trapezoidal avoids most trouble yjlee168 2013-05-22 08:25
      • Multiple peaks: fallback to linear trapezoidal Helmut 2013-05-22 20:25
        • Multiple peaks: fallback to linear trapezoidal yjlee168 2013-05-22 21:57
          • No interpolation Helmut 2013-05-22 23:25
            • No interpolation yjlee168 2013-05-23 11:43
              • Spaghetti & other pasta Helmut 2013-05-23 15:15
                • Spaghetti & other pasta yjlee168 2013-05-23 20:47
                  • Spaghetti & other pasta Helmut 2013-05-23 21:29
                    • Spaghetti & other pasta yjlee168 2013-05-23 22:46
                      • Spaghetti & other pasta Helmut 2013-05-24 01:24
                        • Spaghetti & other pasta yjlee168 2013-05-24 09:17
            • No interpolationKen Peh 2013-05-30 19:55
              • Different algos! Helmut 2013-05-30 22:38
                • Different algos! Ken Peh 2013-06-03 17:52
                  • Calculate what? Helmut 2013-06-03 18:11
      • Lin-up/log-down trapezoidal example Helmut 2013-05-25 15:09
        • Lin-up/log-down trapezoidal example yjlee168 2013-05-25 19:45
  • handling of missing data Ohlbe 2013-05-20 21:45
    • Sorry Helmut 2013-05-21 13:53
      • Sorry gracehung 2013-05-23 01:06
        • Uncertain time point Helmut 2013-05-23 01:35