Bioequivalence and Bioavailability Forum • No interpolation

No interpolation [NCA / SHAM]

posted by yjlee168 – Kaohsiung, Taiwan, 2013-05-23 13:43 (4409 d 19:18 ago) – Posting: # 10626
Views: 20,083

Dear Helmut,

Thanks for your messages, and the codes works well now.

❝ ...

❝ Relax. Would make only sense if the user has a choice. Some people still get crazy if one tries anything else than the linear trapezoidal.

Yes, that's my concern too. I should provide users options for this step in NCA. It should be easy to implement such a function with bear at the moment.

❝ Don’t use my code without improving it! In its current form it will not work with NAs and/or isolated BQLs within the profile.

Sure and thanks for your reminding.

❝ ...

❝ ❝ Otherwise, the line should not be connected in that way. It should be connected as the line that the arrow points.

❝

❝ Why?

Sorry, I thought it was using lin-up/log-down algo and plots in slide#17.

—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

handling of missing data gracehung 2013-05-20 07:35 [NCA / SHAM]
- Lin-up/log-down trapezoidal avoids most trouble Helmut 2013-05-20 14:22
  - Lin-up/log-down trapezoidal avoids most trouble yjlee168 2013-05-22 08:25
    - Multiple peaks: fallback to linear trapezoidal Helmut 2013-05-22 20:25
      - Multiple peaks: fallback to linear trapezoidal yjlee168 2013-05-22 21:57
        
        No interpolation Helmut 2013-05-22 23:25
        
        No interpolationyjlee168 2013-05-23 11:43
        
        Spaghetti & other pasta Helmut 2013-05-23 15:15
        
        Spaghetti & other pasta yjlee168 2013-05-23 20:47
        
        Spaghetti & other pasta Helmut 2013-05-23 21:29
        
        Spaghetti & other pasta yjlee168 2013-05-23 22:46
        
        Spaghetti & other pasta Helmut 2013-05-24 01:24
        
        Spaghetti & other pasta yjlee168 2013-05-24 09:17
        
        No interpolation Ken Peh 2013-05-30 19:55
        
        Different algos! Helmut 2013-05-30 22:38
        
        Different algos! Ken Peh 2013-06-03 17:52
        
        Calculate what? Helmut 2013-06-03 18:11
    - Lin-up/log-down trapezoidal example Helmut 2013-05-25 15:09
      - Lin-up/log-down trapezoidal example yjlee168 2013-05-25 19:45
- handling of missing data Ohlbe 2013-05-20 21:45
  - Sorry Helmut 2013-05-21 13:53
    - Sorry gracehung 2013-05-23 01:06
      - Uncertain time point Helmut 2013-05-23 01:35