Bioequivalence and Bioavailability Forum • Lin-up/log-down trapezoidal avoids most trouble

Lin-up/log-down trapezoidal avoids most trouble [NCA / SHAM]

posted by yjlee168 – Kaohsiung, Taiwan, 2013-05-22 10:25 (4786 d 22:44 ago) – Posting: # 10614
Views: 24,702

Dear Helmut,

Great. However is there any special consideration when using lin-up/log-down trapezoidal rule to calculate AUCs if there is more than one absorption peak? Thanks in advance.

❝ ...

❝ I always suggest to use the lin-up/log-down trapezoidal method. I think that Pharsight will make it even the default in the next version of Phoenix/WinNonlin. No need to impute data. Fine unless the missing might be C_max… See also this presentation about different integration algos (especially slides 16–17 on what happens with missing values).

—
All the best,
-- Yung-jin Lee
bear v2.9.6:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

Complete thread:

handling of missing data gracehung 2013-05-20 07:35 [NCA / SHAM]
- Lin-up/log-down trapezoidal avoids most trouble Helmut 2013-05-20 14:22
  - Lin-up/log-down trapezoidal avoids most troubleyjlee168 2013-05-22 08:25
    - Multiple peaks: fallback to linear trapezoidal Helmut 2013-05-22 20:25
      - Multiple peaks: fallback to linear trapezoidal yjlee168 2013-05-22 21:57
        
        No interpolation Helmut 2013-05-22 23:25
        
        No interpolation yjlee168 2013-05-23 11:43
        
        Spaghetti & other pasta Helmut 2013-05-23 15:15
        
        Spaghetti & other pasta yjlee168 2013-05-23 20:47
        
        Spaghetti & other pasta Helmut 2013-05-23 21:29
        
        Spaghetti & other pasta yjlee168 2013-05-23 22:46
        
        Spaghetti & other pasta Helmut 2013-05-24 01:24
        
        Spaghetti & other pasta yjlee168 2013-05-24 09:17
        
        No interpolation Ken Peh 2013-05-30 19:55
        
        Different algos! Helmut 2013-05-30 22:38
        
        Different algos! Ken Peh 2013-06-03 17:52
        
        Calculate what? Helmut 2013-06-03 18:11
    - Lin-up/log-down trapezoidal example Helmut 2013-05-25 15:09
      - Lin-up/log-down trapezoidal example yjlee168 2013-05-25 19:45
- handling of missing data Ohlbe 2013-05-20 21:45
  - Sorry Helmut 2013-05-21 13:53
    - Sorry gracehung 2013-05-23 01:06
      - Uncertain time point Helmut 2013-05-23 01:35