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Registerhandling of missing data [NCA / SHAM]
Dear Gracehung,
I understand you question differently from Helmut. My understanding is that the sample was collected, but the phlebotomist failed to record the actual blood sampling time. In such a case I would just file a protocol deviation and re-train the staff, full stop. Even if there were a sampling time deviation, the influence on the AUC 90 % CI is so limited that it would only change the outcome of the trial in a very borderline situation.
❝ As in BE study, One sample’s actual sampling time was miss recorded. However as according to protocol, this sample was analyzed by our analytical laboratory.
I understand you question differently from Helmut. My understanding is that the sample was collected, but the phlebotomist failed to record the actual blood sampling time. In such a case I would just file a protocol deviation and re-train the staff, full stop. Even if there were a sampling time deviation, the influence on the AUC 90 % CI is so limited that it would only change the outcome of the trial in a very borderline situation.
—
Regards
Ohlbe
Regards
Ohlbe
Complete thread:
- handling of missing data gracehung 2013-05-20 07:35 [NCA / SHAM]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Lin-up/log-down trapezoidal avoids most trouble Helmut 2013-05-20 14:22
- Lin-up/log-down trapezoidal avoids most trouble yjlee168 2013-05-22 08:25
- Multiple peaks: fallback to linear trapezoidal Helmut 2013-05-22 20:25
- Multiple peaks: fallback to linear trapezoidal yjlee168 2013-05-22 21:57
- No interpolation Helmut 2013-05-22 23:25
- No interpolation yjlee168 2013-05-23 11:43
- Spaghetti & other pasta Helmut 2013-05-23 15:15
- Spaghetti & other pasta yjlee168 2013-05-23 20:47
- Spaghetti & other pasta Helmut 2013-05-23 21:29
- Spaghetti & other pasta yjlee168 2013-05-23 22:46
- Spaghetti & other pasta Helmut 2013-05-24 01:24
- Spaghetti & other pasta yjlee168 2013-05-24 09:17
- Spaghetti & other pasta Helmut 2013-05-24 01:24
- Spaghetti & other pasta yjlee168 2013-05-23 22:46
- Spaghetti & other pasta Helmut 2013-05-23 21:29
- Spaghetti & other pasta yjlee168 2013-05-23 20:47
- Spaghetti & other pasta Helmut 2013-05-23 15:15
- No interpolation Ken Peh 2013-05-30 19:55
- Different algos! Helmut 2013-05-30 22:38
- Different algos! Ken Peh 2013-06-03 17:52
- Calculate what? Helmut 2013-06-03 18:11
- Different algos! Ken Peh 2013-06-03 17:52
- Different algos! Helmut 2013-05-30 22:38
- No interpolation yjlee168 2013-05-23 11:43
- No interpolation Helmut 2013-05-22 23:25
- Multiple peaks: fallback to linear trapezoidal yjlee168 2013-05-22 21:57
- Lin-up/log-down trapezoidal example Helmut 2013-05-25 15:09
- Lin-up/log-down trapezoidal example yjlee168 2013-05-25 19:45
- Multiple peaks: fallback to linear trapezoidal Helmut 2013-05-22 20:25
- Lin-up/log-down trapezoidal avoids most trouble yjlee168 2013-05-22 08:25
- handling of missing dataOhlbe 2013-05-20 21:45
- Sorry Helmut 2013-05-21 13:53
- Sorry gracehung 2013-05-23 01:06
- Uncertain time point Helmut 2013-05-23 01:35
- Sorry gracehung 2013-05-23 01:06
- Sorry Helmut 2013-05-21 13:53
- Lin-up/log-down trapezoidal avoids most trouble Helmut 2013-05-20 14:22
Ing. Helmut Schütz