Bioequivalence and Bioavailability Forum • Compound Symmetry

Compound Symmetry [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2013-05-02 16:41 (4011 d 00:28 ago) – Posting: # 10524
Views: 21,926

Hi Detlew & John,

❝ […] try to use a simple model, f.i. neglect s2D which in turn results in a CS variance-covariance structure for the random part. Sometimes this helps.

Nice – no warnings in PHX any more (only two iterations with the default settings).

log AUCt

PE: 94.7377 (90% CI: 87.4898 – 102.586) Final variance parameter estimates: csDiag_11 0.00843516 csBlock_11 0.187534 Var(Period*Formulation*Subject)_21 0.0530102 Var(Period*Formulation*Subject)_22 0.0715068

log AUCi

PE: 95.2967 (90% CI: 88.4014 – 102.730) Final variance parameter estimates: csDiag_11 -0.00942047 csBlock_11 0.147924 Var(Period*Formulation*Subject)_21 0.0624828 Var(Period*Formulation*Subject)_22 0.0898627

What do you SASians get?

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Helmut Schütz

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Complete thread:

FDA's HVD SAS Code from Progesterone Guidance jag009 2013-04-22 16:39 [RSABE / ABEL]
- Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47
  - Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
    - SAS vs. PHX Helmut 2013-04-22 22:10
      - SAS vs. PHX Shuanghe 2013-04-23 11:45
        
        SAS vs. SAS d_labes 2013-04-23 16:50
        
        SAS vs. SAS vs. Phoenix Helmut 2019-11-12 13:01
      - SAS vs. PHX jag009 2013-04-23 15:56
        
        SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
        
        Nut Job.. jag009 2013-04-30 21:09
        
        Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
        
        Second opinion (PHX 6.3) jag009 2013-05-01 17:16
        
        Second opinion (PHX 6.3) ElMaestro 2013-05-01 18:48
        In praise of a full replicate Helmut 2013-05-01 19:16
        Third opinion d_labes 2013-05-02 12:00
        
        Compound SymmetryHelmut 2013-05-02 14:41
        
        Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
        
        Variance=0 Helmut 2013-05-03 16:07